Regular article| Volume 96, ISSUE 6, P467-472, December 15, 1999

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Exercise Induces a Change in Plasma Fibrinogen Concentration

Fact or Fiction?
  • Mahmoud S El-Sayed
    Corresponding author: Prof. Mahmoud. S. El-Sayed, The Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, The Henry Cotton Campus, Webster Street, Liverpool, L3 2ET, England. Tel: +44(151)231 4321; Fax: +44(151)231 4353
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, England, UK.
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  • Peter G.W Jones
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, England, UK.
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  • Craig Sale
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, England, UK.
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      This study examined the effect of exercise on plasma fibrinogen concentrations with simultaneous measurements of plasma volume changes. Eight moderately active males aged 26.6±3.6 years (mean±SD) completed maximal (VO2max) and submaximal (75% VO2max for 30 minutes) exercise trials separated by 7 days. Venous blood samples were obtained at rest, immediately postexercise, and following 30 minutes of recovery. Whole blood was analysed for haematocrit and haemoglobin, while citrated plasma was assayed for fibrinogen levels. Values of haematocrit and haemoglobin before and after exercise were utilised for the estimation of plasma volume changes. Plasma volume decreased (p<0.05) immediately following both maximal (−17.7±5.1%) and submaximal (−14.3±4.1%) exercise. Exercise resulted in decreased plasma fibrinogen levels (maximal exercise: from 266.3±14.5 to 222.2±23.9 mg·dL−1; submaximal exercise: from 239.5±45.4 to 209.7±42.4 mg·dL−1) only when postexercise raw data were corrected for the contraction of plasma volume. It is concluded therefore that changes in plasma volume in response to exercise should be taken into account when interpreting exercise effects on plasma fibrinogen concentration.



      Hct, haematocrit (), Hb, haemoglobin (), ANOVA, analysis of variance ()
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