Abstract
Accumulating evidence suggests that the ELISA determination of D-Dimer might be a
useful tool for the exclusion of deep vein thrombosis (DVT) of lower extremities,
because of its high sensitivity and negative predictive value. However, conventional
ELISA assay is time-consuming and, therefore, is not suitable for emergency use. To
evaluate the accuracy of two rapid assays recently described, 126 consecutive outpatients
with the clinical suspicion of DVT underwent the NycoCard D-Dimer and the Instant
I.A. D-Dimer determination, using venography as the reference test. In all patients,
the conventional ELISA assay was also performed. Venography confirmed the presence
of DVT in 30 patients (23.8%), and ruled out the diagnosis in the remaining 96. Instant
I.A D-Dimer was positive in 28 patients with DVT (sensitivity, 93.3%), and negative
in 90 subjects free from thrombosis (specificity, 93.8%). Nycocard D-Dimer correctly
identified 27 patients with DVT (sensitivity 90.0%), and was negative in 77 subjects
free from thrombosis (specificity, 80.2%). Sensitivity, specificity, negative and
positive predictive values of both tests did not differ from those found with the
classic ELISA method. In conclusion, both Instant I.A. D-Dimer and Nycocard D-Dimer
assays show a great potential for clinical use.
© 1997 Elsevier Science Ltd
Keywords
Abbreviations:
ELISA (enzyme linked immunoassay)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
February 2,
1997
Received in revised form:
February 2,
1997
Received:
September 19,
1996
Identification
Copyright
© 1997 Elsevier Science Ltd. Published by Elsevier Inc. All rights reserved.
