Abstract
The aim of this study was to investigate the hemostatic system in menopausal women
before and after three months of treatment with transdermal estradiol (TTS 50, 50
μg/die, n=13) or conjugated equine estrogen (CEE, 0.625 mg/die, n=9) by evaluating
: beta-thromboglobulin, platelet factor 4, factor VIIag, factor VIIc, fibrinopeptide
A-FPA-, thrombin-antithrombin-TAT-complexes, antithrombin-AT-activity, protein C,
plasma fibrinolytic activity (euglobulin clot lysis time), plasminogen and antiplasmin
activity. FPA levels significantly increased during TTS 50 treatment (p<0.001) while
protein C showed a slight but significant decrease in both treatments (TTS 50 p<0.001,
CEE p< 0.05). TAT complexes and AT were found unaltered. Platelet function and fibrinolytic
activity did not significantly change. A significant relationship between FPA and
estradiol levels, which were significantly increased during TTS 50 therapy, was found
(r = 0.40, p<0.05). These findings indicate that unopposed estradiol given by transdermal
route induces a slight but significant blood clotting activation, which seems strictly
related to its biological activity. Copyright © 1997 Elsevier Science Ltd
Keywords
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Article info
Publication history
Accepted:
November 19,
1996
Received in revised form:
November 19,
1996
Received:
July 4,
1996
Identification
Copyright
© 1997 Elsevier Science Ltd. Published by Elsevier Inc. All rights reserved.
