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Letter to the Editors-in-Chief|Articles in Press

Calculate incidence rates of BNT162b2-related arterial or venous thrombosis only from the entire cohort of interest

Published:February 03, 2023DOI:https://doi.org/10.1016/j.thromres.2023.01.027
      We read with interest the article by Walton et al. about a self-controlled case series using national hospitalisation and immunisation records about the incidence of venous and arterial thrombosis among 6039 vaccinees hospitalised for thrombosis within three weeks following vaccination with the BNT162b2 vaccine in New Zealand during an observational period from 19th February 2021 through 19th February 2022 [
      • Walton M.
      • Tomkies R.
      • Teunissen T.
      • Lumley T.
      • Hanlon T.
      Thrombotic events following the BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) in aotearoa New Zealand: a self-controlled case series study.
      ]. It was found that 5127 vaccinees had venous thromboembolism, 605 arterial thrombosis, 272 splanchnic thrombosis, and 35 venous sinus thrombosis, which was not different from an appropriate control group [
      • Walton M.
      • Tomkies R.
      • Teunissen T.
      • Lumley T.
      • Hanlon T.
      Thrombotic events following the BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) in aotearoa New Zealand: a self-controlled case series study.
      ]. The study is appealing but carries limitations that raise concerns and should be discussed.

      Keywords

      Abbreviations:

      BNT162b2 (Biontech Pfizer vaccine)
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      References

        • Walton M.
        • Tomkies R.
        • Teunissen T.
        • Lumley T.
        • Hanlon T.
        Thrombotic events following the BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) in aotearoa New Zealand: a self-controlled case series study.
        Thromb. Res. 2022 Dec; 28: 102-108https://doi.org/10.1016/j.thromres.2022.12.012
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