Postpartum hemorrhage (PPH) continues to be the leading preventable cause of maternal
morbidity and mortality worldwide. Although many risk factors have been identified,
this life-threatening complication often occurs in women who have no clear identifiable
risk factors [
[1]
].Abbreviations:
ART (assisted reproductive technologies), BMI (body mass index), CI (confidence interval), CS (caesarean section), IQR (interquartile range), LMWHs (low-molecular-weight heparins), PPH (postpartum hemorrhage), RR (relative risk), VTE (venous thrombo-embolism), WHO (World Health Organization), aRR (adjusted relative risk)Keywords
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References
- Incidence, risk factors, and temporal trends in severe postpartum hemorrhage.Am. J. Obstet. Gynecol. 2013 Nov; 209: 449.e1-449.e7https://doi.org/10.1016/j.ajog.2013.07.007
- Low molecular weight heparins (LMWH) and implications along pregnancy: a focus on the placenta.Reprod. Sci. 2021 Jul 6; https://doi.org/10.1007/s43032-021-00678-0
- Low molecular weight heparin use during pregnancy and risk of postpartum hemorrhage: a systematic review and meta-analysis.J. Matern. Fetal Neonatal Med. 2019 Jun; 32: 1893-1900https://doi.org/10.1080/14767058.2017.1419179
- The risk of postpartum hemorrhage in women using high dose of low-molecular-weight heparins during pregnancy.Thromb. Res. 2012 Sep; 130: 334-338https://doi.org/10.1016/j.thromres.2012.03.007
- Haemorrhagic complications of peripartum anticoagulation: a retrospective chart review.Obstet. Med. 2014 Jun; 7: 77-83https://doi.org/10.1177/1753495X14520849
- The safety of low molecular weight heparin therapy during labor.J. Matern. Fetal Neonatal Med. 2005 Jan; 17: 39-43https://doi.org/10.1080/14767050400028626
- Low-molecular-weight heparin in pregnancy: peripartum bleeding complications.J. Perinatol. 2007 Jun; 27: 329-334https://doi.org/10.1038/sj.jp.7211745
- Timing of postpartum enoxaparin administration and severe postpartum hemorrhage.Blood Coagul. Fibrinolysis. 2008 Jan; 19: 55-59https://doi.org/10.1097/MBC.0b013e3282f185dd
- A double centre retrospective study into rates of postpartum haemorrhage in women on low molecular weight heparin.Br. J. Haematol. 2017 Jan; 176: 141-143https://doi.org/10.1111/bjh.13939
- Incidence of postpartum haemorrhage in women receiving therapeutic doses of low-molecular-weight heparin: results of a retrospective cohort study.BMJ Open. 2011 Nov 14; 1e000257https://doi.org/10.1136/bmjopen-2011-000257
- Prenatal anemia and postpartum hemorrhage risk: a systematic review and meta-analysis.J. Obstet. Gynaecol. Res. 2021 Aug; 47: 2565-2576https://doi.org/10.1111/jog.14834
- Oxytocic activity of thrombin: modulation of thrombin-induced gravid rat myometrial contractions by 5-hydroxytryptamine receptor antagonists.J. Perinat. Med. 2004; 32: 126-131https://doi.org/10.1515/JPM.2004.023
- Effects of thrombin on myometrial contractions in vitro and in vivo.Am. J. Obstet. Gynecol. 2000 Oct; 183: 799-804https://doi.org/10.1067/mob.2000.108897
- Mechanisms of thrombin-induced myometrial contractions: potential targets of progesterone.PLoS One. 2020 May 4; 15e0231944https://doi.org/10.1371/journal.pone.0231944
- Tissue factor-dependent thrombin generation across pregnancy.Am. J. Obstet. Gynecol. 2012 Aug; 207: 135.e1-135.e6https://doi.org/10.1016/j.ajog.2012.05.027
Article info
Publication history
Published online: December 17, 2022
Accepted:
December 15,
2022
Received in revised form:
November 29,
2022
Received:
October 14,
2022
Identification
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© 2022 Elsevier Ltd. All rights reserved.
