Very high risk of intracranial hemorrhage and severe outcomes in adult patients with mild hemophilia: Sub-analysis of the EMO.REC Registry

Published:November 23, 2022DOI:
      Patients with mild hemophilia are usually considered low risk for spontaneous bleeding, such that they are rarely prescribed prophylaxis with clotting factor concentrates. Their natural history is undoubtedly more favorable than that of patients with moderate or severe hemophilia and they have a life expectancy very close to that of the general population [
      • Franchini M.
      • Favaloro E.J.
      • Lippi G.
      Mild hemophilia a.
      ]. However, advancing age also leads to an increase in typical diseases of adulthood and the elderly which increase bleeding risks, such as hypertension, cancer, and cardiac or cerebrovascular diseases, in patients with mild hemophilia, necessitating careful patient monitoring and initiation or modification of antihaemorrhagic therapy to reduce bleeding outcomes [
      • Franchini M.
      • Favaloro E.J.
      • Lippi G.
      Hemophilia, cancer and cardiovascular disease.


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