Highlights
- •Platelets function as immune cells, directly linking coagulation and immunity.
- •Platelets respond to pathogens by direct recognition or in response to inflammatory stimuli from other immune cells.
- •Platelets represent a key regulator between protective hemostasis and pathogenic immunothrombosis.
Abstract
Platelets are anucleated cells derived from megakaryocytes that are primarily responsible
for hemostasis. However, in recent years, these cytoplasts have become increasingly
recognized as immune cells, able to detect, interact with, and kill pathogens. As
platelets are involved in both immunity and coagulation, they have a central role
in immunothrombosis, a physiological process in which immune cells induce the formation
of microthrombi to both prevent the spread of pathogens, and to help facilitate clearance.
In this review, we will highlight the role of platelets as key players in the inflammatory
and innate immune response against bacterial and viral infection, including direct
and indirect interactions with pathogens and other immune cells.
Keywords
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Article info
Publication history
Published online: October 13, 2022
Accepted:
October 3,
2022
Received in revised form:
September 28,
2022
Received:
July 29,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
