Highlights
- •SSNHL patients have higher CD62p or PAC-1 positive platelets than healthy subjects.
- •Additional PGE1 treatment leads to more hearing gain than regular treatment.
- •PGE1 further reduces excessive platelet activation in SSNHL patients.
- •Higher initial CD62p and PAC-1 predict better clinical efficacy of PGE1 treatment.
Abstract
Perspectives
To evaluate the treatment outcome of vasodilator prostaglandin E1 (PGE1) in treating
sudden sensorineural hearing loss (SSNHL) and to determine its effects on platelet
activation, as reflected by changes in CD62p and PAC-1.
Methods
We prospectively enrolled 60 patients with confirmed SSNHL and randomly divided them
into two groups: the SSNHL group received regular therapy, and the SSNHL-PGE1 group
received additional intravenous injection of PGE1. After 14 days of treatment, we
measured clinical improvement and CD62p-positive and PAC-1-positive platelets. 30
healthy medical staff members were included as a control group.
Results
The SSNHL patients had significantly higher levels of CD62p-positive or PAC-1 positive
platelets than the healthy subjects. The ratios of CD62p positive or PAC-1 positive
platelets significantly decreased after the two treatments. The average pure tone
(PTA) hearing thresholds decreased to 26.51 ± 12.65 dB in SSNHL-PGE1 group after treatment,
which was significantly lower than that of the SSNHL group (34.46 ± 10.35 dB). Patients
with initial severe or profound hearing loss (PTA ≥ 71 dB) had better hearing improvement
on PGE1 than on the regular treatment. Patients in the SSNHL-PGE1 treatment group
had significantly lower CD62p and PAC-1 levels than those in the SSNHL group. Patients
with higher initial positive CD62p and PAC-1 ratios tended to have higher potential
of clinical improvement and hearing gains after PGE1 treatment. Initial CD62p and
PAC-1 levels were significantly correlated with hearing thresholds in patients with
SSNHL.
Conclusion
PGE1 application could improve treatment efficacy and suppress excessive platelet
activation in patients with SSNHL.
Keywords
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Article info
Publication history
Published online: January 23, 2020
Accepted:
January 22,
2020
Received in revised form:
January 20,
2020
Received:
May 16,
2019
Identification
Copyright
© 2020 Elsevier Ltd. All rights reserved.
