30 years of developmental haemostasis: what have we learnt and how are we applying this knowledge

  • Vera Ignjatovic
    Corresponding author at: Senior Research Fellow Haematology Research Laboratory, Murdoch Children’s Research Institute, Principal Fellow, Honorary, Department of Paediatrics, The University of Melbourne. Address: Haematology Research Laboratory / Murdoch Children’s Research Institute, Flemington Road, Parkville, Victoria, 3052, Australia. Tel.: +61 3 99366520.
    Murdoch Children’s Research Institute, Royal Children’s Hospital, Victoria 3052, Australia

    Department of Paediatrics, The University of Melbourne, Royal Children’s Hospital, Victoria 3052, Australia
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      Developmental haemostasis, the concept describing age-specific differences in the haemostatic system was born out of seminal studies led by Maureen Andrew in late 1980s and early 1990s. Those studies, for the first time, defined the normal changes in haemostatic protein expression and activity in healthy neonates and children as compared to adults. Until then, the knowledge and clinical investigations of haemostasis were largely based on adults.
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