Highlights
- •The overall incidence of immune thrombocytopenia was 2.59/100,000 person-years.
- •Hepatitis B and C only in immune thrombocytopenia patients were higher in Taiwan.
- •Hyperthyroidism and hypothyroidism increased risks of immune thrombocytopenia.
- •Serious bleeding among immune thrombocytopenia patients was low.
Abstract
Introduction
Immune thrombocytopenia (ITP) is an immune-mediated disease; it has been reported
to be associated with several diseases. The data on ITP in patients with hepatitis
B, tuberculosis, or thyroid diseases are relatively scarce. In addition, these diseases
are not rare in Taiwan, together with hepatitis C and Helicobacter pylori which are also related to ITP.
Methods and materials
We identified 1223 ITP patients and characterized these patients between 2000 and
2013 from the National Health Insurance Research Database. The adult ITP patients
were matched with non-ITP patients.
Results
The overall incidence of ITP was 2.59/100,000 person-years. The frequencies of hepatitis
B and C in adult ITP patients were much higher than those indicated in previous studies.
The frequencies of non-traumatic intracerebral hemorrhage and gastrointestinal bleeding
during hospitalization among ITP patients were low. The diseases associated with increased
risks of ITP included hepatitis B (OR = 18.70, 95% CI = 9.71–36.03), hepatitis C (OR = 54.43,
95% CI = 15.94–185.88), hepatitis B and hepatitis C (OR = 7.02, 95% CI = 1.47–33.56),
tuberculosis (OR = 5.37, 95% CI = 2.72–10.61), Helicobacter pylori infection (OR = 5.93, 95% CI = 3.16–11.10), hyperthyroidism (OR = 3.43, 95% CI = 2.09–5.64),
hypothyroidism (OR = 6.70, 95% CI = 2.35–19.13), and simple and unspecified goiter
(OR = 2.68, 95% CI = 1.43–5.03).
Conclusions
Surveying for the diseases which are frequent and related to increased risks of ITP
among patients with newly diagnosed ITP should be considered.
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Article info
Publication history
Published online: February 27, 2018
Accepted:
February 25,
2018
Received in revised form:
January 31,
2018
Received:
August 8,
2017
Identification
Copyright
© 2018 Elsevier Ltd. All rights reserved.
