Abstract
The identification of specific post-thrombotic complications as well as an increased
appreciation of the importance of patient-reported outcome measures have triggered
an interest in studying health-related quality of life (HRQoL) in patients with a
history of venous thromboembolism (VTE).
In order to enable a comprehensive assessment of HRQoL in clinical trials it is recommended
that both generic and disease-specific questionnaires be used. SF-36 and EQ-5D are
the most widely used generic questionnaires in VTE studies, whereas several disease-specific
questionnaires have been developed to evaluate HRQoL following deep vein thrombosis
(DVT) and in chronic venous disease (CVD). The most widely used of these is the VEINES-QOL/Sym, which was developed for CVD. VT-QOL and DVTQOL are both questionnaires developed to evaluate HRQoL after DVT, while PEmb-QoL is
currently the only available disease-specific questionnaire developed specifically
for pulmonary embolism (PE).
Although studies show inconsistent results, patients who sustain DVT seem in general
to report similar HRQoL compared to the general population. However, patients who
develop PTS after DVT report poorer HRQoL using both generic and disease-specific
questionnaires. HRQoL appears to be impaired in patients who sustain PE compared to
the general population. In these patients, persistent dyspnea after PE has been shown
to be a predictor of reduced HRQoL.
Further work is needed to develop practical, patient-derived, valid, reliable and
responsive disease-specific HRQoL instruments covering the specific aspects of these
diseases.
Keywords
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Article info
Publication history
Published online: July 23, 2017
Accepted:
July 21,
2017
Received in revised form:
July 14,
2017
Received:
May 7,
2017
Footnotes
☆This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Identification
Copyright
© 2017 Elsevier Ltd. All rights reserved.
