Abstract
The antiplatelet and antithrombotic effects of YS-49 and YS-51—l-naphthylmethyl analogs
of higenamine, which is a benzyl-tetrahydroisoquinoline alkaloid isolated from Aconitum japonicum (Ranunculaceae)—were investigated. YS-49 and YS-51 showed inhibitory activities to
both human and rat platelet aggregation induced by ADP, collagen and epinephrine.
They were more inhibitory to epinephrine-induced aggregation (IC50; 3.4 and 1.7 μM of YS-49, and 6.0 and 6.3 μM of YS-51 to human and rat platelets,
respectively) than ADP- or collagen-induced aggregation. The antithrombotic effects
of YS-49 and YS-51 were also observed in both mouse acute thrombosis model and rat
arterio-venous shunt (AV shunt) model. The oral administration of YS-49 and YS-51
(50 or 100 mg/kg) increased the recovery rates from the acute thrombotic challenge
in mice and lowered the weight of thrombus formed inside the AV shunt tube in rats.
Keywords
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Article info
Publication history
Accepted:
August 27,
2001
Received in revised form:
August 27,
2001
Received:
May 10,
2001
Identification
Copyright
© 2001 Elsevier Science Ltd. Published by Elsevier Inc. All rights reserved.
