Abstract
Background
Cancer patients with venous thromboembolism (VTE) have an increased incidence of recurrences
and bleeding complications Reliable information on the factors determining the risk
for such complications may facilitate better use of therapy.
Methods
RIETE Registry is an ongoing, international registry of consecutive patients presenting
with symptomatic acute VTE confirmed by objective tests. We assessed the 3-month outcome
in all women with active cancer, trying to identify if differences exist according
to the tumor site.
Results
Up to May 2007, 18,883 patients had been enrolled. Of them, 3805 (20%) had active
cancer, 1719 (45%) were women. During the 3-month study period, 40 (2.3%) had recurrent
deep vein thrombosis, 39 (2.3%) recurrent pulmonary embolism (PE), 67 (3.9%) major
bleeding, 394 (23%) died. Of these, 13 (33%) women with recurrent PE died of the PE,
17 (42%) with major bleeding had fatal bleeding. In women with gastrointestinal (5.7%
vs. 4.3%) or genitourinary (6.4% vs. 4.7%) cancers the incidence of bleeding complications
exceeded that of VTE recurrences, while in those with brain (3.4% vs. 13%) or lung
cancer (2.6% vs. 11%) the rate of recurrences outweighed that of major bleeding.
Conclusions
We identified significant differences in outcome according to the site of cancer that
may help to identify those women with cancer and VTE at a higher risk for recurrences
or major bleeding.
Keywords
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Article info
Footnotes
Conflicts of interest: This article is original work that has not been previously published in any substantial part and is not under consideration for publication elsewhere. All authors have read and approved this manuscript, and they meet the criteria for authorship, including acceptance of responsibility for the scientific content of the manuscript. All authors contributed to the research presented in this manuscript and had full access to all data and hold final responsibility for the decision to submit this manuscript to Thromb Res for publication. No author has any conflict of interest.
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Copyright
© 2009 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
