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Paper| Volume 48, ISSUE 5, P559-565, December 01, 1987

Platelet storage lesion: Formation of platelet fragments with platelet factor 3 activity

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      Abstract

      Certain samples of stored platelet concentrates exhibited marked platelet factor 3 activity. This activity was associated almost completely with platelet fragments formed during storage. Platelet concentrates containing high levels of these fragments and hence high platelet factor 3 activity were characterized after storage by alkaline plasma pH values, high levels of extracellular lactate dehydrogenase activity and relatively low cell counts.

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