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Paper| Volume 48, ISSUE 5, P511-518, December 01, 1987

An extract of feverfew inhibits interactions of human platelets with collagen substrates

DOI:https://doi.org/10.1016/0049-3848(87)90383-5
An extract of feverfew inhibits interactions of human platelets with collagen substrates
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      Abstract

      The interaction of platelets with surfaces coated with collagens of type III (C III) or IV (C IV) has been studied by measuring the deposition of 51-Cr-labeled platelets and by scanning electron microscopy (SEM). Experiments were performed using platelet-rich plasma (PRP) and suspensions of gel-filtered platelets (GFP). Platelets were deposited on C III mainly as surfacebound aggregates. In contrast they were deposited on C IV mainly as spread forms of individual cells. Formation of aggregates on C III was more extensive for PRP than for GFP; in contrast platelet spreading on C IV was more extensive for GFP than for PRP. The effects of an extract of the plant feverfew on platelet-collagen interactions were determined. Fever few extract inhibited the deposition of 51-Cr-labeled platelets on both C III and C IV in a dose-dependent way. Similar concentrations of extract were needed to inhibit the formation of surface-bound aggregates and to inhibit platelet spreading in both PRP and GFP.

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      Article info

      Publication history

      Accepted: September 24, 1987
      Received: March 3, 1987

      Identification

      DOI: https://doi.org/10.1016/0049-3848(87)90383-5

      Copyright

      © 1987 Published by Elsevier Inc.

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