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Paper| Volume 40, ISSUE 6, P823-831, December 15, 1985

Glutathione levels in human platelets display a circadian rhythm in vitro

  • E. Radha
    Affiliations
    Departments of Laboratory Medicine & Pathology and the Department of Pediatrics, University of Minnesota Health Sciences Center, Box 198 Mayo Memorial Building, Minneapolis, Minnesota 55455 USA
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  • Timothy D. Hill
    Affiliations
    Departments of Laboratory Medicine & Pathology and the Department of Pediatrics, University of Minnesota Health Sciences Center, Box 198 Mayo Memorial Building, Minneapolis, Minnesota 55455 USA
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  • Gundu H.R. Rao
    Affiliations
    Departments of Laboratory Medicine & Pathology and the Department of Pediatrics, University of Minnesota Health Sciences Center, Box 198 Mayo Memorial Building, Minneapolis, Minnesota 55455 USA
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  • James G. White
    Affiliations
    Departments of Laboratory Medicine & Pathology and the Department of Pediatrics, University of Minnesota Health Sciences Center, Box 198 Mayo Memorial Building, Minneapolis, Minnesota 55455 USA
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DOI:https://doi.org/10.1016/0049-3848(85)90319-6
Glutathione levels in human platelets display a circadian rhythm in vitro
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      Abstract

      Glutathione (GSH) levels were measured in platelet-rich plasma (PRP) and concentrates at 4 hour intervals during storage. The values fell steadily during the first several hours after collection at 9:00 a.m., reaching the lowest level at midnight, 14 hours later. Subsequently, the levels rose to a new peak value at 4:00 a.m. GSH levels continued to show cyclic variation over the 48 hours examined in this study. Change in schedules of light and dark under which the platelets were stored had no effect on GSH periodicity. Platelets from night shift workers also displayed a similar periodicity to that of day workers. Erythrocytes failed to demonstrate a similar time related variation in GSH levels during storage.

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      Article info

      Publication history

      Accepted: September 20, 1985
      Received: July 5, 1985

      Identification

      DOI: https://doi.org/10.1016/0049-3848(85)90319-6

      Copyright

      © 1985 Published by Elsevier Inc.

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