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Abstract
Mesenteries of mice under anesthesia were stretched over an inverted microscope. A
micropipette filled with solution containing various concentrations of ADP or thrombin
was brought into contact with the outside of a mesenteric vein by micromanipulation,
and then poured over the outer surface of the vein. Morphological characteristics
of the thrombi and the time needed for thrombus formation were examined. Application
of either thrombin or ADP to the adventitia of mesenteric veins caused thrombus formation.
Although thrombi by application of ADP seemed to be anchored by direct adhesion of
platelets to the exposed subendothelium, thrombi by application of thrombin seemed
to be anchored by deposited fibrin.
Keywords
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Article info
Publication history
Accepted:
September 3,
1985
Received:
June 7,
1985
Identification
Copyright
© 1985 Published by Elsevier Inc.
