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Paper| Volume 37, ISSUE 6, P669-679, March 15, 1985

Antithemostatic and antthrombotic effects of capsaicin in comparison with aspirin and indomethacin

DOI:https://doi.org/10.1016/0049-3848(85)90196-3
Antithemostatic and antthrombotic effects of capsaicin in comparison with aspirin and indomethacin
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      Abstract

      Capsaicin prolonged the tail bleeding time in the conscious mice. This effect was dose-dependent and maximal effect was observed at 3 hr after the oral administration. Capsaicin was effective in preventing death caused by ADP-induced acute pulmonary thromboembolism in mice at dose of 25 mg/kg, while aspirin and indomethacin had no effect at 200 mg/kg. Capsaicin also reduced the mortality in collagen- and sodium arachidonate-induced thromboembolic death at dose of 25 and 50 mg/kg, respectively, and aspirin and indomethacin were also effective in these models but only when the dose was higher than 200 mg/kg. Capsaicin, aspirin or indcmethacin could not protect mice from endotoxin shock. Capsaicin was found to suppress platelet aggregation markedly, but did not affect blood coagulation. In conclusion, capsaicin was proved to be more effective than aspirin and indomethacin in preventing the death of acute pulmonary thromboembolism, and this effect could be due to its inhibition on platelet aggregation.

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      Article info

      Publication history

      Accepted: January 3, 1985
      Received: October 1, 1984

      Identification

      DOI: https://doi.org/10.1016/0049-3848(85)90196-3

      Copyright

      © 1985 Published by Elsevier Inc.

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