Paper| Volume 37, ISSUE 6, P669-679, March 15, 1985

Antithemostatic and antthrombotic effects of capsaicin in comparison with aspirin and indomethacin

      This paper is only available as a PDF. To read, Please Download here.


      Capsaicin prolonged the tail bleeding time in the conscious mice. This effect was dose-dependent and maximal effect was observed at 3 hr after the oral administration. Capsaicin was effective in preventing death caused by ADP-induced acute pulmonary thromboembolism in mice at dose of 25 mg/kg, while aspirin and indomethacin had no effect at 200 mg/kg. Capsaicin also reduced the mortality in collagen- and sodium arachidonate-induced thromboembolic death at dose of 25 and 50 mg/kg, respectively, and aspirin and indomethacin were also effective in these models but only when the dose was higher than 200 mg/kg. Capsaicin, aspirin or indcmethacin could not protect mice from endotoxin shock. Capsaicin was found to suppress platelet aggregation markedly, but did not affect blood coagulation. In conclusion, capsaicin was proved to be more effective than aspirin and indomethacin in preventing the death of acute pulmonary thromboembolism, and this effect could be due to its inhibition on platelet aggregation.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Thrombosis Research
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Toch C.C.
        • Lee T.S.
        • Kiang A.K.
        The pharmacological actions of capsaicin and analogues.
        Br. J. Pharmacol. 1955; 10: 175-182
        • Buck S.H.
        • Burks T.F.
        Capsaicin: hot new pharmacological tool.
        Trends. Pharmacol. Sci. 1983; 4: 84-87
        • Coleridge H.M.
        • Coleridge J.C.
        Impulse activity in afferent vagal C-fibers with endings in the intrapulmonary airways of drugs.
        Respir. Physiol. 1977; 29: 125-142
        • Foster R.W.
        • Ramage A.G.
        The action of some chemical irritants on somatosensory receptors of the cat.
        Neuropharmacology. 1981; 20: 191-198
        • Szolcsányi J.
        A pharmacological approach to elucidation of the role of different nerve fibers and receptor endings in medication of pain.
        J. Physiol. (Paris). 1977; 73: 251-259
        • Alarie Y.
        • Keller L.W.
        Sensory irritation by capsaicin.
        Environ. Physiol. Biochem. 1973; 3: 169-181
        • Szolcsányi J.
        • Jancsó-Gábor A.
        • Joo F.
        Functional and fine structural characteristics of the sensory neuron blocking effect of capsaicin.
        Naunyn-Schmiedeberg's Arch. Pharmacol. 1975; 287: 157-169
        • Theriault E.
        • Otsuka M.
        • Jessell T.
        Capsaicin-evokes release of substance P from primary sensory neurons.
        Brain Res. 1979; 170: 209-213
        • Gamse R.
        • Molnar A.
        • Lembecc F.
        Substance P release from spinal cord slices by capsaicin.
        Life Sci. 1979; 24: 629-636
        • Jancso G.
        • Kiraly E.
        • Jancso-Gabor A.
        Direct evidence for an axonal site of action of capsaicin.
        Naunyn-Schmiedeber's Arch. Pharmacol. 1980; 313: 91-94
        • Thomas D.P.
        The platelet contribution to arterial and venous thrombosis.
        Clin. Haematol. 1972; 1: 267-282
        • Mustard J.F.
        • Packham M.A.
        Factors influencing platelet function: adhesion, release and aggregation.
        Pharmacol. Rev. 1970; 22: 97-187
        • Umetsu T.
        • Sanai K.
        Effect of 1-methyl-2-mercapto-5-(3-pyridyl)-imidazole (KC-6141), an anti-aggregating compound, on experimental thrombosis in rats.
        Thrombos. Haemostas. 1978; 39: 74-83
        • Tomikawa M.
        • Ashida S.
        • Kakihata K.
        • Abiko Y.
        Antithrombotic action of ticlopidine, a new platelet aggregation inhibitor.
        Thrombos, Res. 1978; 12: 1157-1164
        • Evans G.E.
        Effects of drugs that suppress platelet surfact interaction on incidence of amaurosis fugax and transient cerebral ischemia.
        Surg. Forum. 1972; 23: 239-244
        • Kaegi A.
        • Pined G.F.
        • Shimizu A.
        • Trivedi H.
        • Hirsh J.
        • Gent M.
        Arteriovenous-shunt thrombosis prevention by sulfinpyrazone.
        New Engl. J. Med. 1974; 290: 304-306
        • Wang J.P.
        • Hsu M.F.
        • Teng C.M.
        Antiplatelet effect of capsaicin.
        Thrombos. Res. 1984; (in press)
        • Hornstra G.
        • Christ-Hazelholf E.
        • Haddeman E.
        • Ten H.F.
        • Nugsteren D.H.
        Fish oil feeding lower thromboxane and prostacyclin production by rat platelets or aorta and does not result in the formation of prostagland I3.
        Prostaglandin. 1981; 21: 727-738
        • Nordoy A.
        • Chandler A.B.
        Platelet thrombosis induced by adenosine diphosphate in the rat.
        Scand. J. Haematol. 1964; 1: 16-25
        • Nishizawa E.E.
        • Wynalda D.J.
        • Suydam D.E.
        • Sawa T.R.
        • Schulz J.R.
        Collagen-induced pulmonary thromboembolism in mice.
        Thrombos. Res. 1972; 1: 233
        • Fleming J.S.
        • Bierwagesi M.E.
        • Losada M.
        • Campbell J.A.L.
        • King S.P.
        • Pindell M.H.
        The effects of three antiinflammatory agents on platelet aggregation, in vitro and in in vivo.
        Arch. Int. Pharmacodyn. Ther. 1970; 186: 120-128
        • O'Brien J.R.
        Platelet aggregation II. Some results from a new method of study.
        J. Clin. Pathol. 1962; 15: 452-455
        • Yamazaki H.
        • Takahashi T.
        • Sano T.
        Hyperaggregability of platelets in thromboembolic disorders.
        Thrombos. Diathes. Haemostas. 1975; 34: 94-105
        • Harter H.
        Klinische Bllutgerinnungsstudien Mit der Thrombela-stographie.
        Dtsch. Archiv f. Klinisch. Medizin. 1952; 199: 284
        • Fahrenholtz K.E.
        • Silverzweig M.Z.
        • Germane N.
        • Crowley H.J.
        • Simko B.A.
        • Dalton C.
        3-phenyl-5-[2, 2 2-trifluoro-l-hydroxy-1-(trifluoromethyl)ethyl]indole-2-carbonitrile, a potent inhibitor of prostaglandin synthetase and platelet aggregation.
        J. Med. Chem. 1979; 22: 948-953
        • Silver M.J.
        • Hoch W.
        • Kocsis J.J.
        • Ingerman C.M.
        • Smith J.B.
        Arachidonic acid causes sudden death in rabbit.
        Science. 1974; 183: 1085-1186
        • Kelton J.G.
        • Hirsh J.
        • Carter C.J.
        • Buchanan M.R.
        Thrombogenic effect of high dose aspirin in rabbit, relationship to inhibition of vessel wall synthesis of prostaglandin I2-like activity.
        J. Clin. Invest. 1978; 62: 892-895
        • Burch J.W.
        • Baenziger N.L.
        • Standford N.
        • Majerus P.W.
        Sensitivity of fatty acid cyclooxygenase from human aorta is acetylation by aspirin.
        in: Proc. Natl. Acad. Sci. U.S.A.75. 1978: 5181-5184
        • Villa S.
        • Livio M.
        • de Gaetano G.
        The inhibitory effect of aspirin on platelet and vascular prostaglandins in rats cannot be completely dissociated.
        Br. J. Haematol. 1979; 42: 425-431
        • Baenziger N.L.
        • Becherer P.R.
        • Majerus P.W.
        characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblast.
        Cell. 1979; 16: 967-974
        • Thomas D.P.
        • Wessler S.
        Stasis thrombi induced by bacterial endotoxin.
        Circ. Res. 1964; 14: 486-493
        • Corrigan Jr., J.J.
        Effect of anticoagulating and non-anticoagulating concentrations of heparin on the generalized Shwartzman reaction.
        Thrombos. Diathes. Haemostas. 1970; 24: 136-145