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Abstract
The effect of fibrin degradation products (FDP) on pulmonary transvascular fluid and
protein exchange was examined in the sheep lung lymph fistula preparation. The pulmonary
lymph was used to assess changes in pulmonary lymph flow (Qlym) (a measure of net
transvascular fluid filtration rate) and the lymph/plasma protein concentration ratio
(L/P) (a measure of protein seiving across the microvascular barrier). Studies were
made in 3 groups: Control Thrombin (n=7) received 96.9±9.4 U/kg of α-thrombin, Control-FDP
(n=6) received infusion of FDP prepared by plasmin digestion of fibrin, and Thrombin-FDP
(n=5) received thrombin (102.0±7.5 U/kg) and then an FDP infusion was begun at 60
min after the thrombin. In the Control-Thrombin animals, Qlym increased withoug a
change in the L/P after thrombin, indicating an increase in vascular permeability
to proteins. In the Control-FDP group, infusion of FDP had no effect on Qlym and L/P.
In the Thrombin-FDP group, thrombin increased Qlym with no change in the L/P and the
subsequent infusion of FDP further increased Qlym but slightly decreased the L/P,
an effect not seen in the Control-FDP group. The results indicate that FDP infusion
alone does not alter pulmonary transvascular fluid and protein exchange. However,
in the presence of thrombin-induced pulmonary microembolization FDP infusion enhances
the net transvascular fluid filtration rate, probably by increasing the capillary
hydrostatic pressure.
Keywords
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Publication history
Accepted:
October 25,
1984
Received:
July 6,
1984
Footnotes
☆Supported by HL-17355, HL-26551, and HL-27016 from the National Institutes of Health.
Identification
Copyright
© 1985 Published by Elsevier Inc.
