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Abstract
Changes in fibrinolysis, platelets and coagulation during hypothermia were investigated
in anesthetized dogs. Strong activation of plasma fibrinolysis was observed in the
hypothermia group. The maximum fibrinolytic activity determined with standard fibrin
plates was markedly higher than that of the control sample (mean values: 67 and 15
mm2/0.03 ml plasma, respectively). On the other hand, no fibrinolysis was observed by
the plasminogen free plate method. Activation was not observed in the control group
or the hypothermia group premedicated with chlorpromazine. The platelet count was
decreased from 100% to 14.7% and the collagen induced platelet aggregability from
61% to 2.3% during hypothermia. Recovery from both reductions occurred on rewarming.
In the control and premedicated groups, the recalcification time was reduced progressively
(from 93.6 to 60.9 sec and from 101.1 to 71.8 sec as mean times, respectively). The
tendencey towards shortening of the recalcification time was not related to the core
temperature.
Keywords
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Article info
Publication history
Accepted:
December 3,
1984
Received in revised form:
October 31,
1984
Received:
August 10,
1984
Identification
Copyright
© 1985 Published by Elsevier Inc.
