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Levels of fibrinogen and thromboelastometry fibrin polymerisation following treatment with desmopressin (DDAVP)
01 February 2012
Benny Sørensen, Gary Moore, Gerald Hochleitner, Christian Fenger-Eriksen
Introduction. Patients who have received platelet inhibitory drugs may constitute a challenge in management of perioperative bleeding . Administration of DDAVP has been proposed to be effective in par...
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Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade
30 January 2012
Laurent Bonello, Laurence Camoin-Jau, Julien Mancini, Jacques Bessereau, Charlotte Grosdidier, Marie-Christine Alessi, Michel Ostorero, Françoise Dignat-George, Franck Paganelli
Abstract: Introduction: Inter-individual variability in clopidogrel responsiveness is dependent on genetic polymorphisms. We aimed to investigate the impact of 3 genetic polymorphisms involved in clop...
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Continuous thrombin infusion leads to a bleeding phenotype in sheep
30 January 2012
Jolanta M. Siller-Matula, Ingrid Miller, Manfred Gemeiner, Roberto Plasenzotti, Guenther Bayer, Ildiko Mesteri, Astrid Fabry, Karin Petroczi, Katharina Nöbauer, Ebrahim Razzazi-Fazeli, Sébastien Planchon, Jenny Renaut, Peter Quehenberger, Edgar Selzer, Bernd Jilma
Abstract: Background: In addition to a recognized role in the coagulation cascade and haemostasis, thrombin is known to have multiple functions. We aimed to establish an ovine model to study thrombin ...
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Incomplete resolution of deep vein thrombosis under reduced flow conditions
30 January 2012
Brian C. Cooley, Chao-Ying Chen, Ryan Hess, Gregory Schmeling
Abstract: Introduction: Post-thrombotic syndrome is a major complication of deep vein thrombosis (DVT), occurring in up to 1/3 of first-episode DVT patients. Non-ambulatory patients have increased ris...
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Prospective Study of the Frequency and Outcomes of Patients with Suspected Pulmonary Embolism Administered Heparin Prior to Confirmatory Imaging
30 January 2012
Jeffrey A. Kline, Michael R. Marchick, Christopher Kabrhel, D. Mark Courtney
Abstract: Objectives: The administration of empiric systemic anticoagulation (ESA) before confirmatory radiographic testing in patients with suspected pulmonary embolism (PE) may improve outcomes, but...
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