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Editorial Board
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IFC
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Elevated plasma factor VIII levels in patients with venous thrombosis – Constitutional risk factor or secondary epiphenomenon?
28 October 2011
Whilst elevated plasma factor VIII (FVIII) levels has long been associated with increased risk of arterial disease, its potential importance as a risk factor for venous thromboembolism (VTE) only emer...
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Kevin Ryan,
James S. O'Donnell
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105-106
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| Reviews |
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Use of anticoagulants in elderly patients
20 October 2011
Abstract: Thromboembolic disorders are a major cause of morbidity and mortality, and the risk of thromboembolism increases with age. Anticoagulants are recommended for indications including the preven...
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Rupert M. Bauersachs
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107-115
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Platelet dysfunction in vascular pathologies and how can it be treated
31 October 2011
Abstract: Cardiovascular diseases are one of the leading causes of morbidity and mortality in industrialized countries, and although many processes play a role in the development of vascular disease, ...
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Nicoleta Alexandru,
Doina Popov,
Adriana Georgescu
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116-126
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Risk assessment models for thromboprophylaxis of medical patients
02 November 2011
In spite of epidemiologic studies and updated international guidelines, more than 50% of hospitalised patients for an acute medical condition do not receive prophylactic treatment for venous thrombo-e...
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Meyer M. Samama,
Sophie Combe,
Jacqueline Conard,
Marie-Helene Horellou
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127-132
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| Original Articles |
| Clinical Studies |
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Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: A case-control study
01 August 2011
Abstract: Introduction: Our aim was to investigate the association of elevated homocysteine (Hcy) and lipoprotein(a) Lp(a) with the prevalence of coronary artery disease (CAD) and myocardial infarctio...
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Emilia Balogh,
Zsuzsanna Bereczky,
Éva Katona,
Zsolt Kőszegi,
István Édes,
László Muszbek,
István Czuriga
et al.
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133-138
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Physician and patient perceptions of the route of administration of venous thromboembolism prophylaxis: Results from an international survey
04 August 2011
Abstract: Introduction: Acceptability of a prescribed treatment regimen is crucial to its clinical success, and the route of drug administration can play an important role in determining acceptability...
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Claudio Cimminiello,
Frederick A. Anderson
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139-145
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Thromboembolic safety and efficacy of prothrombin complex concentrates in the emergency reversal of warfarin coagulopathy
02 August 2011
Abstract: Background: There is uncertainty regarding the efficacy and incidence of thromboembolic events in patients treated with prothrombin complex concentrates (PCC) for the emergency reversal of w...
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Ammar Majeed,
Anna Eelde,
Anna Ågren,
Sam Schulman,
Margareta Holmström
et al.
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146-151
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Elevated soluble endothelial cell protein C receptor (sEPCR) levels in women with preeclampsia: A marker of endothelial activation/damage?
09 August 2011
Abstract: The endothelial protein C receptor (EPCR) plays a crucial role in the anticoagulant and anti-inflammatory effects of the protein C pathway, whereas its soluble form (sEPCR) exhibits opposite...
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Béatrice Saposnik,
Edith Peynaud-debayle,
Alain Stepanian,
Gabriel Baron,
Maud Simansour,
Laurent Mandelbrot,
Dominique de Prost,
Sophie Gandrille
et al.
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152-157
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| Platelets and Cell Biology |
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Impact of altered venous hemodynamic conditions on the formation of platelet layers in thromboemboli
03 October 2011
Abstract: Although it is generally believed that the structure of venous thromboemboli is a homogeneous red blood cell-fibrin clot, their structure may be heterogeneous, with non-uniformly distributed...
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Franci Bajd,
Jernej Vidmar,
Andrej Fabjan,
Aleš Blinc,
Eduard Kralj,
Nina Bizjak,
Igor Serša
et al.
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158-163
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Systemic and local factors associated with coronary plaque disruption
05 October 2011
Abstract: Introduction: Yellow plaques are regarded vulnerable; and disrupted yellow plaques are the major cause of acute coronary syndrome. We examined the factors associated with the disruption of y...
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Yasunori Ueda,
Koshi Matsuo,
Mayu Nishio,
Akio Hirata,
Takayoshi Nemoto,
Mitsutoshi Asai,
Ayaka Murakami,
Kazunori Kashiwase,
Kazuhisa Kodama
et al.
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164-168
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Anopheline anti-platelet protein from a malaria vector mosquito has anti-thrombotic effects in vivo without compromising hemostasis
11 October 2011
Abstract: Introduction: The saliva of blood-feeding animals (e.g., mosquitoes, ticks, bats) has pharmacological activities that facilitate efficient blood-sucking. We previously identified a unique an...
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Hideki Hayashi,
Hiroyuki Kyushiki,
Keisuke Nagano,
Toshiki Sudo,
Hiroyuki Matsuoka,
Shigeto Yoshida
et al.
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169-175
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Purification, biochemical properties and antithrombotic effect of a novel Streptomyces enzyme on carrageenan-induced mice tail thrombosis model
10 October 2011
Abstract: Introduction: The prevalence of cardiovascular diseases, one of the major causes of worldwide mortality, is being increasingly reported. Safer, more effective, and less expensive thrombolyti...
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Jaya Ram Simkhada,
Seung Sik Cho,
Poonam Mander,
Yun Hee Choi,
Jin Cheol Yoo
et al.
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176-182
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| Coagulation and Fibrinolysis |
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The acute phase reaction explains only a part of initially elevated factor VIII:C levels: A prospective cohort study in patients with venous thrombosis
13 October 2011
Abstract: We determined in a prospective cohort of patients treated with vitamin K antagonists for venous thrombosis, the course of factor VIII (FVIII:C), C-reactive protein (CRP) and fibrinogen level...
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Vladimir Tichelaar,
André Mulder,
Hanneke Kluin-Nelemans,
Karina Meijer
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183-186
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Harmonization and external quality assessment of antithrombin activity assays
11 July 2011
Abstract: In the framework of a Dutch project named “Calibration 2000” harmonization of antithrombin activity assays was studied. The commutability of potential calibrators for antithrombin was assess...
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Anton M.H.P. van den Besselaar,
Fred J.L.M. Haas,
Aldy W.H.M. Kuypers
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187-191
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Variable plasma levels of Factor V Leiden correlate with circulating platelet microparticles in carriers of Factor V Leiden
28 July 2011
Abstract: Introduction: Inheritance of Factor V Leiden (FVL) is associated with an increased but variable level of risk for thrombosis. We have previously shown that FVL heterozygotes have elevated le...
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Lisa F. Lincz,
Fiona E. Scorgie,
Anoop Enjeti,
Michael Seldon
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192-196
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Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity
15 July 2011
Abstract: Introduction: Cancer associated thrombosis is a well-recognized phenomenon that results in considerable patient morbidity and mortality. Malignancy conveys an increased risk for thrombosis a...
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Jeremiah C. Boles,
Julie C. Williams,
Rachel M. Hollingsworth,
Jian-Guo Wang,
Sam L. Glover,
A. Phillip Owens,
David A. Barcel,
Raj S. Kasthuri,
Nigel S. Key,
Nigel Mackman
et al.
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197-203
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| Letters to the Editors-in-Chief |
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Obesity-related Coagulation Changes in Pregnancy
12 September 2011
Obesity, a health concern of increasing importance in developed countries, is associated with a four- to five-fold increased risk of venous thromboembolism (VTE) in pregnancy . In one study, obese pre...
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Michael P. Smrtka,
Betty Thames,
Michele Beckman,
Dimple Rajgor,
Mihir Gandhi,
Andra H. James
et al.
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204-206
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When the game demons take real lives: A call for global awareness raising for venous Thromboembolism
31 October 2011
The sad story of the death of a 20year-old man who succumbed to pulmonary embolism following prolonged immobility, due to playing computer games for several hours, was lately reported in the media. V...
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Behnood Bikdeli
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207
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Urinary excretion of iPF2α-III predicts the risk of future thrombotic events. A 10-year follow-up
31 October 2011
Oxidative modifications of cell membrane lipids and of circulating lipoproteins induced by oxygen reactive species play a key role in thrombogenesis and atherogenesis. F2-isoprostanes are prostagland...
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Matteo Nicola Dario Di Minno,
Viviana Cavalca,
Armando D'angelo,
Isabella Squellerio,
Antonio Coppola,
Elena Tremoli,
Giovanni Di Minno
et al.
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208-211
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CYP2C19 gene variants cut-off levels for on-clopidogrel platelet aggregation
28 October 2011
Sir, a recent report on CYP2C19 gene variants cut-off levels for on-clopidogrel platelet aggregation is very interesting . Ono et al. concluded that “the cut-off levels of PRU and %inhibition to discr...
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Viroj Wiwanitkit
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212
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Tamibarotene-induced low-grade reversible intravascular coagulation in a patient with acute promyelocytic leukemia
08 August 2011
All-trans retinoic acid (ATRA) has proven to be a major advance in the management of patients with acute promyelocytic leukemia (APL). Several studies show that treatment regimens containing ATRA for ...
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Kinya Ohata,
Hirohito Yamazaki,
Hidesaku Asakura,
Shigeru Shimadoi,
Shinji Nakao
et al.
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213-214
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Clinical usefulness of a high-concentration calcium chloride solution method to correct the activated partial thromboplastin time in a high hematocrit model with heparin therapy
26 September 2011
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Masaaki Kanahara,
Haruhito Harada,
Hiroshi Niiyama,
Atsushi Katoh,
Hisashi Kai,
Hisao Ikeda
et al.
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215-217
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