Thrombosis Research
Volume 127, Supplement 3 , Pages S67-S71, February 2011

Microparticles and pregnancy complications

  • Anat Aharon

      Affiliations

    • Thrombosis and Hemostasis Unit, Rambam Health Care Campus, Haifa, Israel
    • Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    • Corresponding Author InformationCorresponding author. Anat Aharon, PhD. Thrombosis and Hemostasis Unit, Rambam Health Care Campus, P.O. Box 9602, Haifa 31096, Israel. Tel.: +97248543520; fax: +97248543886
    • ,
  • Benjamin Brenner

      Affiliations

    • Thrombosis and Hemostasis Unit, Rambam Health Care Campus, Haifa, Israel
    • Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

Abstract 

Microparticles (MPs) are shed from cell membranes of a variety of cells, promote thrombus formation, mediate pro-inflammatory effects and may cause endothelial dysfunction. Normal pregnancy is characterized by increased levels of MPs compared to non-pregnant healthy women but the prevalence, cell origin and the role of MPs in pregnancy-related complications remain controversial.

Normal pregnancy is an acquired hyper-coagulable state due to an increase in procoagulants and decrease in natural anticoagulants. Pregnancy-related complications such as preeclampsia, intrauterine fetal growth restriction (IUGR) and fetal loss are associated with placental dysfunction and may cause significant maternal and fetal morbidity and mortality.

This article highlights the role of microparticles in maternal placental crosstalk and the interplay between microparticles, thrombosis and pregnancy complications.

Keywords:  Microparticles (MPs) , Pregnancy complications , Placenta , Trophoblasts

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PII: S0049-3848(11)70019-6

doi:10.1016/S0049-3848(11)70019-6

Thrombosis Research
Volume 127, Supplement 3 , Pages S67-S71, February 2011

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