Thrombosis Research
Volume 127, Supplement 3 , Pages S51-S52, February 2011

APS – controversies in diagnosis and management, critical overview of current guidelines

  • Vittorio Pengo

      Affiliations

    • Corresponding Author InformationCorrespondence: Vittorio Pengo M.D. Clinical Cardiology, Thrombosis Center, Dept. of Cardiac Thoracic and Vascular Sciences, Via Giustiniani 2, 35128 Padova, Italy. Tel.:+390498215658; fax: +390498215658

Clinical Cardiology, Thrombosis Center, University of Padova School of Medicine, Padova, Italy

Abstract 

Because the diagnosis of antiphospholipid syndrome is based on laboratory data, performance and interpretation of such tests is essential. Positivity in a single test among Lupus Anticoagulant (LA), anti cardiolipin (aCL) and anti β2-glycoprotein I (aβ2GPI) antibodies calls APS diagnosis into question. Conversely, triple positivity is strongly associated to thrombosis and pregnancy morbidity. A new era in studying APS should take into account different antiphospholipid antibodies profiles. Clinical studies on groups of patients that are homogeneous in terms of laboratory tests will provide information on the real risk of patients and on the real effect of therapeutic interventions.

Keywords:  Antiphospholipid syndrome (APS) , Diagnosis , Patient laboratory profile , Therapeutic interventions

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PII: S0049-3848(11)70014-7

doi:10.1016/S0049-3848(11)70014-7

Thrombosis Research
Volume 127, Supplement 3 , Pages S51-S52, February 2011

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