Association between adiponectin gene polymorphisms and coronary artery disease across different populations

Zhou, Liang; Xi, Bo; Wei, Yuan; Pan, Haiyan; Yang, Wanshui; Shen, Weihua; Li, Yixiang; Cai, Jianguang; Tang, Hui

doi:10.1016/j.thromres.2011.12.028

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Association between adiponectin gene polymorphisms and coronary artery disease across different populations

Liang Zhou
- Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan 411201, China
- Corresponding author at: Department of Physical Education, Hunan University of Science and Technology, Xiangtan 411201, China. Tel./fax: +86 731 58291443.
- Liang Zhou and Bo Xi contributed equally to this work.
Bo Xi
- Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, China
- Liang Zhou and Bo Xi contributed equally to this work.
Yuan Wei
- Department of Sports Physiology, Guangzhou Sports University, Guangzhou 510075, China
Haiyan Pan
- Department of Epidemiology and Biostatistics, Guangdong Medical College, Dongwan 523808, China
Wanshui Yang
- Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
Weihua Shen
- Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan 411201, China
Yixiang Li
- Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan 411201, China
Jianguang Cai
- Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan 411201, China
Hui Tang
- Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan 411201, China

Received 3 September 2011; received in revised form 7 December 2011; accepted 22 December 2011. published online 19 January 2012.
Corrected Proof

Abstract

Objective

Many studies have suggested that adiponectin gene might be involved in the development of coronary artery disease (CAD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to assess the associations of +45T/G, +276G/T and −11377C/G polymorphisms in adiponectin gene with CAD susceptibility.

Methods

Published literature from PubMed and EMBASE databases were searched. Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated using fixed- or random-effects model.

Results

Sixteen studies (4394 cases / 8187 controls) for +45T/G polymorphism, fifteen studies (3569 cases / 7463 controls) for +276G/T polymorphism, and thirteen studies (3531 cases / 7072 controls) for −11377C/G polymorphism were included in the meta-analysis. The overall results showed that there was a statistically significant association between −11377C/G polymorphism and CAD (G vs. C: OR=1.15, 95%CI 1.07-1.24).Similar results were observed among European (G vs. C: OR=1.11, 95%CI 1.02-1.20) and East Asian populations (G vs. C: OR=1.27, 95%CI 1.11-1.45). However, no significant association was found for +45T/G or +276G/T polymorphism with CAD susceptibility.

Conclusions

The meta-analysis indicated the significant association of −11377C/G polymorphism, but not +45T/G or +276G/T polymorphism, with CAD susceptibility. However, large-scale studies with the consideration of gene-gene and gene-environment interactions should be conducted to investigate the associations in future.

Keywords: Adiponectin, Polymorphism, Coronary artery disease, Meta-analysis