Thrombosis Research
Volume 125 , Pages S108-S116 , April 2010

Lessons from French national guidelines on the treatment of venous thrombosis and central venous catheter thrombosis in cancer patients

  • Dominique Farge

      Affiliations

    • Service de médecine interne et pathologie vasculaire, Hôpital Saint-Louis and INSERM U976, Assistance Publique Hôpitaux de Paris, France
    • Corresponding Author InformationCorresponding author. Dominique Farge, MD, PhD, Service de médecine interne et pathologie vasculaire, Hôpital Saint-Louis and INSERM U976, Assistance Publique Hôpitaux de Paris, 1 avenue Claude-Vellefaux, 75010 Paris, France
    • ,
  • Cecile Durant

      Affiliations

    • Service de médecine interne et pathologie vasculaire, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, France
    • ,
  • Stéphane Villiers

      Affiliations

    • Département d'Anesthésie Réanimation, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, France
    • ,
  • Anne Long

      Affiliations

    • Service de PathologieVasculaire, Hôpital Robert Debré, CHU Reims, France
    • ,
  • Alfred Mahr

      Affiliations

    • Service de Médecine Interne, Hôpital Cochin, Assistance Publique Hôopitaux de Paris, France
    • ,
  • Michel Marty

      Affiliations

    • Service de Cancérologie, Hôpital Desgenettes Lyon, CHU Reims, France
    • ,
  • Philippe Debourdeau

      Affiliations

    • Service de Cancérologie, Hôpital Desgenettes Lyon, CHU Reims, France
    • ,
  • for the Groupe Francophone Thrombose et Cancer (GFTC)

References 

  1. Heit JA , Silverstein MD , Mohr DN , Petterson TM , O'Fallon WM , Melton LJ . Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study . Arch Intern Med . 2000;160(6):809–815
  2. Spencer FA , Lessard D , Emery C , Reed G , Goldberg RJ . Venous thromboembolism in the outpatient setting . Arch Intern Med . 2007;167(14):1471–1475
  3. Levitan N , Dowlati A , Remick SC , Tahsildar HI , Sivinski LD , Beyth R , et al.   Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data . Medicine (Baltimore) . 1999;78(5):285–291
  4. Khorana AA , Francis CW , Culakova E , Kuderer NM , Lyman GH . Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients . Cancer . 2007;110(10):2339–2346
  5. Meyer G , Marjanovic Z , Valcke J , Lorcerie B , Gruel Y , Solal-Celigny P , et al.   Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer: a randomized controlled study . Arch Intern Med . 2002;162(15):1729–1735
  6. Lee AY , Levine MN , Baker RI , Bowden C , Kakkar AK , Prins M , et al.   Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer . N Engl J Med . 2003;349(2):146–153
  7. Hull RD , Pineo GF , Brant RF , Mah AF , Burke N , Dear R , et al.   Long-term low-molecular-weight heparin versus usual care in proximal-vein thrombosis patients with cancer . Am J Med . 2006;119(12):1062–1072
  8. Ferretti G , Bria E , Giannarelli D , Carlini P , Felici A , Mandala M , et al.   Is recurrent venous thromboembolism after therapy reduced by low-molecular-weight heparin compared with oral anticoagulants? . Chest . 2006;130(6):1808–1816
  9. Akl EA , Kamath G , Kim SY , Yosuico V , Barba M , Terrenato I , et al.   Oral anticoagulation may prolong survival of a subgroup of patients with cancer: a cochrane systematic review . J Exp Clin Cancer Res . 2007;26(2):175–184
  10. Kuderer NM , Khorana AA , Lyman GH , Francis CW . A meta-analysis and systematic review of the efficacy and safety of anticoagulants as cancer treatment: impact on survival and bleeding complications . Cancer . 2007;110(5):1149–1161
  11. Akl EA , Barba M , Rohilla S , Terrenato I , Sperati F , Muti P , et al.   Anticoagulation for the long term treatment of venous thromboembolism in patients with cancer . Cochrane Database Syst Rev . 2008;(2): CD006650.
  12. Akl EA , Rohilla S , Barba M , Sperati F , Terrenato I , Muti P , et al.   Anticoagulation for the initial treatment of venous thromboembolism in patients with cancer . Cochrane Database Syst Rev . 2008;(1): CD006649.
  13. Noble SI , Shelley MD , Coles B , Williams SM , Wilcock A , Johnson MJ . Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis . Lancet Oncol . 2008;9(6):577–584
  14. Louzada ML , Majeed H , Wells PS . Efficacy of low-molecular-weight-heparin versus vitamin K antagonists for long term treatment of cancer-associated venous thromboembolism in adults: a systematic review of randomized controlled trials . Thromb Res . 2009;123(6):837–844
  15. Mandala M , Falanga A , Piccioli A , Prandoni P , Pogliani EM , Labianca R , et al.   Venous thromboembolism and cancer: guidelines of the Italian Association of Medical Oncology (AIOM) . Crit Rev Oncol Hematol . 2006;59(3):194–204
  16. Venous thromboembolic disease NCCN guidelines V2.2009. 2009. http://www.nccn.org/professionals/physician_gls/PDF/vte.pdf. Access on 08.01.2010.
  17. Khorana AA . The NCCN Clinical Practice Guidelines on Venous Thromboembolic Disease: strategies for improving VTE prophylaxis in hospitalized cancer patients . Oncologist . 2007;12(11):1361–1370
  18. Lyman GH , Khorana AA , Falanga A , Clarke-Pearson D , Flowers C , Jahanzeb M , et al.   American Society of Clinical Oncology guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer . J Clin Oncol . 2007;25(34):5490–5505
  19. Farge D , Bosquet L , Kassab-Chahmi D , Mismetti P , Elalamy I , Meyer G , et al.   2008 French national guidelines for the treatment of venous thromboembolism in patients with cancer: report from the working group . Crit Rev Oncol Hematol . 2010;73(1):31–46
  20. Debourdeau P , Kassab Chahmi D , Le Gal G , Kriegel I , Desruennes E , Douard MC , et al.   2008 SOR guidelines for the prevention and treatment of thrombosis associated with central venous catheters in patients with cancer: report from the working group . Ann Oncol . 2009;20(9):1459–1471
  21. Geerts WH , Bergqvist D , Pineo GF , Heit JA , Samama CM , Lassen MR , et al.   Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) . Chest . 2008;133(6 Suppl):381S–453S
  22. Kearon C , Kahn SR , Agnelli G , Goldhaber S , Raskob GE , Comerota AJ . Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) . Chest . 2008;133(6 Suppl):454S–545S
  23. Prévention et traitement de la maladie Thromboembolique veineuse. 2009. AFSSAPS. http://www.afssaps.fr/Infos-de-securite/Recommandations-de-bonne-pratique/Prevention-et-traitement-de-la-maladie-thromboembolique-veineuse-en-medecine-recommandations-de-bonne-pratique/(language)/fre-FR. Access on01.08.2010.
  24. Palumbo A , Rajkumar SV , Dimopoulos MA , Richardson PG , San Miguel J , Barlogie B , et al.   Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma . Leukemia . 2008;22(2):414–423
  25. Cohen AT , Tapson VF , Bergmann JF , Goldhaber SZ , Kakkar AK , Deslandes B , et al.   Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study . Lancet . 2008;371(9610):387–394
  26. Kucher N , Spirk D , Kalka C , Mazzolai L , Nobel D , Banyai M , et al.   Clinical predictors of prophylaxis use prior to the onset of acute venous thromboembolism in hospitalized patients SWIss Venous ThromboEmbolism Registry (SWIVTER) . J Thromb Haemost . 2008;6(12):2082–2087
  27. Imberti D , Agnelli G , Ageno W , Moia M , Palareti G , Pistelli R , et al.   Clinical characteristics and management of cancer-associated acute venous thromboembolism: findings from the MASTER Registry . Haematologica . 2008;93(2):273–278
  28. Monreal M , Falga C , Valdes M , Suarez C , Gabriel F , Tolosa C , et al.   Fatal pulmonary embolism and fatal bleeding in cancer patients with venous thromboembolism: findings from the RIETE registry . J Thromb Haemost . 2006;4(9):1950–1956
  29. Seddighzadeh A , Shetty R , Goldhaber SZ . Venous thromboembolism in patients with active cancer . Thromb Haemost . 2007;98(3):656–661
  30. Blom JW , Vanderschoot JP , Oostindier MJ , Osanto S , van der Meer FJ , Rosendaal FR . Incidence of venous thrombosis in a large cohort of 66,329 cancer patients: results of a record linkage study . J Thromb Haemost . 2006;4(3):529–535
  31. White RH , Chew H , Wun T . Targeting patients for anticoagulant prophylaxis trials in patients with cancer: who is at highest risk? . Thromb Res . 2007;120(Suppl 2):S29–S40
  32. Otten HM , Mathijssen J , ten Cate H , Soesan M , Inghels M , Richel DJ , et al.   Symptomatic venous thromboembolism in cancer patients treated with chemotherapy: an underestimated phenomenon . Arch Intern Med . 2004;164(2):190–194
  33. Weijl NI , Rutten MF , Zwinderman AH , Keizer HJ , Nooy MA , Rosendaal FR , et al.   Thromboembolic events during chemotherapy for germ cell cancer: a cohort study and review of the literature . J Clin Oncol . 2000;18(10):2169–2178
  34. Khorana AA . Malignancy, thrombosis and Trousseau: the case for an eponym . J Thromb Haemost . 2003;1(12):2463–2465
  35. Agnelli G , Bolis G , Capussotti L , Scarpa RM , Tonelli F , Bonizzoni E , et al.   A clinical outcome-based prospective study on venous thromboembolism after cancer surgery: the @RISTOS project . Ann Surg . 2006;243(1):89–95
  36. Martino MA , Borges E , Williamson E , Siegfried S , Cantor AB , Lancaster J , et al.   Pulmonary embolism after major abdominal surgery in gynecologic oncology . Obstet Gynecol . 2006;107(3):666–671
  37. Andtbacka RH , Babiera G , Singletary SE , Hunt KK , Meric-Bernstam F , Feig BW , et al.   Incidence and prevention of venous thromboembolism in patients undergoing breast cancer surgery and treated according to clinical pathways . Ann Surg . 2006;243(1):96–101
  38. Verso M , Agnelli G . Venous thromboembolism associated with long-term use of central venous catheters in cancer patients . J Clin Oncol . 2003;21(19):3665–3675
  39. Khorana AA , Francis CW , Culakova E , Kuderer NM , Lyman GH . Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy . J Thromb Haemost . 2007;5(3):632–634
  40. Sorensen HT , Mellemkjaer L , Olsen JH , Baron JA . Prognosis of cancers associated with venous thromboembolism . N Engl J Med . 2000;343(25):1846–1850
  41. Chew HK , Wun T , Harvey D , Zhou H , White RH . Incidence of venous thromboembolism and its effect on survival among patients with common cancers . Arch Intern Med . 2006;166(4):458–464
  42. Mason DP , Quader MA , Blackstone EH , Rajeswaran J , DeCamp MM , Murthy SC , et al.   Thromboembolism after pneumonectomy for malignancy: an independent marker of poor outcome . J Thorac Cardiovasc Surg . 2006;131(3):711–718
  43. Tetsche MS , Norgaard M , Pedersen L , Lash TL , Sorensen HT . Prognosis of ovarian cancer subsequent to venous thromboembolism: a nationwide Danish cohort study . BMC Cancer . 2006;6:189
  44. Alcalay A , Wun T , Khatri V , Chew HK , Harvey D , Zhou H , et al.   Venous thromboembolism in patients with colorectal cancer: incidence and effect on survival . J Clin Oncol . 2006;24(7):1112–1118
  45. Prandoni P , Lensing AW , Piccioli A , Bernardi E , Simioni P , Girolami B , et al.   Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis . Blood . 2002;100(10):3484–3488
  46. Elting LS , Escalante CP , Cooksley C , Avritscher EB , Kurtin D , Hamblin L , et al.   Outcomes and cost of deep venous thrombosis among patients with cancer . Arch Intern Med . 2004;164(15):1653–1661
  47. Nalluri SR , Chu D , Keresztes R , Zhu X , Wu S . Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysis . JAMA . 2008;300(19):2277–2285
  48. Bennett CL , Silver SM , Djulbegovic B , Samaras AT , Blau CA , Gleason KJ , et al.   Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia . JAMA . 2008;299(8):914–924
  49. Mandala M , Falanga A , Roila F . Management of venous thromboembolism in cancer patients: ESMO clinical recommendations . Ann Oncol . 2009;20(Suppl 4):182–184
  50. Wagman LD , Baird MF , Bennett CL , Bockenstedt PL , Cataland SR , Fanikos J , et al.   Venous thromboembolic disease. Clinical practice guidelines in oncology . J Natl Compr Canc Netw . 2006;4(9):838–869
  51. Mandala M , Falanga A , Roila F . Management of venous thromboembolism in cancer patients: ESMO clinical recommendations . Ann Oncol . 2008;19(Suppl 2):ii126–ii127
  52. Development and validation of an international appraisal instrument for assessing the quality of clinical practice guidelines: the AGREE project . Qual Saf Health Care . 2003;12(1):18–23
  53. Hadley SA , Chang M , Rogers K . Effect of syringe size on bruising following subcutaneous heparin injection . Am J Crit Care . 1996;5(4):271–276
  54. Sideras K , Schaefer PL , Okuno SH , Sloan JA , Kutteh L , Fitch TR , et al.   Low-molecular-weight heparin in patients with advanced cancer: a phase 3 clinical trial . Mayo Clin Proc . 2006;81(6):758–767
  55. Balci Akpinar R , Celebioglu A . Effect of injection duration on bruising associated with subcutaneous heparin: a quasi-experimental within-subject design . Int J Nurs Stud . 2008;45(6):812–817
  56. Chan H . Effects of injection duration on site-pain intensity and bruising associated with subcutaneous heparin . J Adv Nurs . 2001;35(6):882–892
  57. Zaybak A , Khorshid L . A study on the effect of the duration of subcutaneous heparin injection on bruising and pain . J Clin Nurs . 2008;17(3):378–385
  58. Kuzu N , Ucar H . The effect of cold on the occurrence of bruising, haematoma and pain at the injection site in subcutaneous low molecular weight heparin . Int J Nurs Stud . 2001;38(1):51–59
  59. Ross S , Soltes D . Heparin and haematoma: does ice make a difference? . J Adv Nurs . 1995;21(3):434–439
  60. Ihnat DM , Mills JL , Hughes JD , Gentile AT , Berman SS , Westerband A . Treatment of patients with venous thromboembolism and malignant disease: should vena cava filter placement be routine? . J Vasc Surg . 1998;28(5):800–807
  61. Opatrny L , Warner MN . Risk of thrombosis in patients with malignancy and heparin-induced thrombocytopenia . Am J Hematol . 2004;76(3):240–244
  62. Prandoni P , Falanga A , Piccioli A . Cancer, thrombosis and heparin-induced thrombocytopenia . Thromb Res . 2007;120(Suppl 2):S137–S140
  63. Warkentin TE . Heparin-induced thrombocytopenia: diagnosis and management . Circulation . 2004;110(18):e454–e458
  64. Klerk CP , Smorenburg SM , Otten HM , Lensing AW , Prins MH , Piovella F , et al.   The effect of low molecular weight heparin on survival in patients with advanced malignancy . J Clin Oncol . 2005;23(10):2130–2135
  65. Noble SI , Finlay IG . Is long-term low-molecular-weight heparin acceptable to palliative care patients in the treatment of cancer related venous thromboembolism? A qualitative study . Palliat Med . 2005;19(3):197–201
  66. Noble SI , Nelson A , Turner C , Finlay IG . Acceptability of low molecular weight heparin thromboprophylaxis for inpatients receiving palliative care: qualitative study . BMJ . 2006;332(7541):577–580
  67. Dranitsaris G , Vincent M , Crowther M . Dalteparin versus warfarin for the prevention of recurrent venous thromboembolic events in cancer patients: a pharmacoeconomic analysis . Pharmacoeconomics . 2006;24(6):593–607
  68. Laupacis A , Feeny D , Detsky AS , Tugwell PX . How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations . CMAJ . 1992;146(4):473–481
  69. Marchetti M , Pistorio A , Barone M , Serafini S , Barosi G . Low-molecular-weight heparin versus warfarin for secondary prophylaxis of venous thromboembolism: a cost-effectiveness analysis . Am J Med . 2001;111(2):130–139
  70. Kryworuchko J , Stacey D , Bai N , Graham ID . Twelve years of clinical practice guideline development, dissemination and evaluation in Canada (1994 to 2005) . Implement Sci . 2009;4:49

 Competing interests: None of the authors have any conflict of interest to declare in relation to this paper.

PII: S0049-3848(10)70027-X

doi: 10.1016/S0049-3848(10)70027-X

Thrombosis Research
Volume 125 , Pages S108-S116 , April 2010

Article Tools