Thrombosis Research
Volume 126, Issue 3 , Pages 227-231 , September 2010

Validation of a rapid test (VWF-LIA) for the quantitative determination of von Willebrand factor antigen in type 1 von Willebrand disease diagnosis within the European multicenter study MCMDM-1VWD

  • G. Castaman

      Affiliations

    • Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    • Corresponding Author InformationCorresponding author. Department of Cellular Therapies and Hematology, San Bortolo Hospital, I-36100 Vicenza, Italy. Tel.: +39 444 753679; fax: +39 444 753922.
    • ,
  • A. Tosetto

      Affiliations

    • Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    • ,
  • A. Cappelletti

      Affiliations

    • Department of Hematology, San Bortolo Hospital, Vicenza, Italy
    • ,
  • A. Goodeve

      Affiliations

    • The Academic Unit of Haematology, University of Sheffield, Sheffield, United Kingdom
    • ,
  • A.B. Federici

      Affiliations

    • Hemophilia and Thrombosis Centre, Foundation IRCCS Maggiore Policlinico Hospital, Mangiagalli Regina Elena and University of Milan, Milan, Italy
    • ,
  • J. Batlle

      Affiliations

    • Servicio de Hematologia y Hemoterapia, Hospital Teresa Herrera, La Coruna, Spain
    • ,
  • D. Meyer

      Affiliations

    • Institut National de la Santè et de la Recherche Médicale, INSERM U143, Paris, France
    • ,
  • J. Goudemand

      Affiliations

    • University of Lille, France
    • ,
  • J.C.J. Eikenboom

      Affiliations

    • Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • R. Schneppenheim

      Affiliations

    • University Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology and Oncology, Hamburg, Germany
    • ,
  • U. Budde

      Affiliations

    • Aesculabor Laboratory, Hamburg, Germany
    • ,
  • J. Ingerslev

      Affiliations

    • Centre for Hemophilia and Thrombosis, University Hospital Skejby, Aarhus, Denmark
    • ,
  • S. Lethagen

      Affiliations

    • Department for Coagulation Disorders, University of Lund, Malmö, Sweden
    • ,
  • F. Hill

      Affiliations

    • Department of Hematology, Children's Hospital Birmingham, United Kingdom
    • ,
  • I.R. Peake

      Affiliations

    • The Academic Unit of Haematology, University of Sheffield, Sheffield, United Kingdom
    • ,
  • F. Rodeghiero

      Affiliations

    • Department of Hematology, San Bortolo Hospital, Vicenza, Italy

Received 17 February 2010 ,Revised 16 June 2010 ,Accepted 17 June 2010.

References 

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  3. Sadler JE, Mannucci PM, Berntorp E, Bochkov N, Boulyjenkov V, Ginsburg D, et al. Impact, diagnosis and treatment of von Willebrand disease. Thromb Haemost. 2000;84:160–174
  4. Castaman G, Eikenboom JCJ, Bertina R, Rodeghiero F. Inconsistency of association between type 1 von Willebrand disease phenotype and genotype in families identified in an epidemiologic investigation. Thromb Haemostas. 1999;82:1065–1070
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  6. Castaman G, Lethagen S, Federici AB, Tosetto A, Goodeve A, Budde U, et al. Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD. Blood. 2008;111:3531–3539
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  14. Villa P, Iborra J, Serra J, Gilsanz A, Casana P, Aznar JA, et al. Evaluation of an automated method for the quantification of von Willebrand factor antigen. Its application in the study of vascular dysfunction. Haematologica. 2001;86:1180–1185
  15. Goodeve A, Eikenboom J, Castaman G, Rodeghiero F, Federici AB, Batlle J, et al. Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD). Blood. 2007;109:112–121
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  18. Tosetto A, Castaman G, Rodeghiero F. Evidence-based diagnosis of type 1 von Willebrand disease: a Bayes theorem approach. Blood. 2008;15(111):3998–4003
  19. Rodeghiero F, Castaman G, Tosetto A. Optimizing treatment of von Willebrand disease by using phenotypic and molecular data. Hematology Am Soc Hematol Educ Program. 2009;113–123

PII: S0049-3848(10)00353-1

doi: 10.1016/j.thromres.2010.06.013

Thrombosis Research
Volume 126, Issue 3 , Pages 227-231 , September 2010

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