Thrombosis Research
Volume 126, Issue 2 , Pages 119-123 , August 2010

The “normal” factor VIII concentration in plasma

  • Saulius Butenas

      Affiliations

    • Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT, USA
    • Corresponding Author InformationCorresponding author. University of Vermont, 208 South Park Drive, Room 235A, Colchester, VT 05446, USA. Tel.: +1 802 656 0350; fax: +1 802 656 2256.
  • ,
  • Behnaz Parhami-Seren

      Affiliations

    • Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT, USA
    • Present address: Moorpark College, Moorpark, CA.
  • ,
  • Anetta Undas

      Affiliations

    • Institute of Cardiology, Jagiellonian University, Krakow, Poland
  • ,
  • David N. Fass

      Affiliations

    • Mayo Medical School, Rochester, MN, USA
  • ,
  • Kenneth G. Mann

      Affiliations

    • Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT, USA

Received 2 February 2010 ,Revised 12 March 2010 ,Accepted 7 April 2010.

References 

  1. Barrowcliffe TW, Raut S, Sands D, Hubbard AR. Coagulation and chromogenic assays of factor VIII activity: general aspects, standardization, and recommendations. Semin Thromb Hemost. 2002;28:247–256
  2. Lundblad RL, Kingdon HS, Mann KG, White GC. Issues with the assay of factor VIII activity in plasma and factor VIII concentrates. Thromb Haemost. 2000;84:942–948
  3. Hubbard AR, Sands D, Sandberg E, Seitz R, Barrowcliffe TW. A multi-centre collaborative study on the potency estimation of ReFacto. Thromb Haemost. 2003;90:1088–1093
  4. Butenas S, Parhami-Seren B, Mann KG. The influence of von Willebrand factor on factor VIII activity measurements. J Thromb Haemost. 2009;7:132–137
  5. Chandler WL, Ferrell C, Lee J, Tun T, Kha H. Comparison of three methods for measuring factor VIII levels in plasma. Am J Clin Pathol. 2003;120:34–39
  6. Cinotti S, Longo G, Messori A, Morfini M, Blomback M, Schimpf K, et al. Reproducibility of one-stage, two-stage and chromogenic assays of factor VIII activity: a multi-center study. Thromb Res. 1991;61:385–393
  7. Hubbard AR, Bevan SA, Weller LJ. Potency estimation of recombinant factor VIII: effect of assay method and standard. Br J Haematol. 2001;113:533–536
  8. Ingerslev J, Jankowski MA, Weston SB, Charles LA. Collaborative field study on the utility of a BDD factor VIII concentrate standard in the estimation of BDDr Factor VIII:C activity in hemophilic plasma using one-stage clotting assays. J Thromb Haemost. 2004;2:623–628
  9. Rodgers SE, Duncan EM, Barbulescu DM, Quinn DM, Lloyd JV. In vitro kinetics of factor VIII activity in patients with mild haemophilia A and a discrepancy between one-stage and two-stage factor VIII assay results. Br J Haematol. 2007;136:138–145
  10. Morfini M, Cinotti S, Bellatreccia A, Paladino E, Gringeri A, Mannucci PM. A multicenter pharmacokinetic study of the B-domain deleted recombinant factor VIII concentrate using different assays and standards. J Thromb Haemost. 2003;1:2283–2289
  11. Raut S, Sands D, Heath AB, Barrowcliffe TW. Variability in factor VIII concentrate measurement: results from SSC field collaborative studies. J Thromb Haemost. 2003;1:1927–1934
  12. Lollar P, Hill-Eubanks DC, Parker CG. Association of the factor VIII light chain with von Willebrand factor. J Biol Chem. 1988;263:10451–10455
  13. Hamer RJ, Koedam JA, Beeser-Visser NH, Bertina RM, Van Mourik JA, Sixma JJ. Factor VIII binds to von Willebrand factor via its Mr-80, 000 light chain. Eur J Biochem. 1987;166:37–43
  14. Tuddenham EG, Lane RS, Rotblat F, Johnson AJ, Snape TJ, Middleton S, et al. Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease. Br J Haematol. 1982;52:259–267
  15. Fass DN, Bowie EJ, Owen CA, Mann KG. Stability of porcine factor VIII. Thromb Res. 1975;6:109–118
  16. Muntean W, Hathaway WE, Montgomery RR. Influence of high molecular weight factor VIII on the measurement of low molecular weight factor VIII procoagulant in different assay systems. Br J Haematol. 1982;51:649–658
  17. Butenas S, Parhami-Seren B, Gissel MT, Gomperts ED, Fass DN, Mann KG. Potency and mass of factor VIII in FVIII products. Haemophilia. 2009;15:63–72
  18. Precup JW, Kline BC, Fass DN. A monoclonal antibody to factor VIII inhibits von Willebrand factor binding and thrombin cleavage. Blood. 1991;77:1929–1936
  19. Fay PJ, Smudzin TM. Intersubunit fluorescence energy transfer in human factor VIII. J Biol Chem. 1989;264:14005–14010
  20. Lollar P, Fay PJ, Fass DN. Factor VIII and factor VIIIa. Methods Enzymol. 1993;222:128–143
  21. Krudysz-Amblo J, Parhami-Seren B, Butenas S, Brummel-Ziedins KE, Gomperts ED, Rivard GE, et al. Quantitation of anti-factor VIII antibodies in human plasma. Blood. 2009;113:2587–2594
  22. Hoyer LW. The factor VIII complex: structure and function. Blood. 1981;58:1–13
  23. Lollar P, Knutson GJ, Fass DN. Stabilization of thrombin-activated porcine factor VIII:C by factor IXa phospholipid. Blood. 1984;63:1303–1308
  24. De Visser MC, Sandkuijl LA, Lensen RP, Vos HL, Rosendaal FR, Bertina RM. Linkage analysis of factor VIII and von Willebrand factor loci as quantitative trait loci. J Thromb Haemost. 2003;1:1771–1776
  25. Souto JC, Almasy L, Muniz-Diaz E, Soria JM, Borrell M, Bayen L, et al. Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time. Arterioscler Thromb Vasc Biol. 2000;20:2024–2028
  26. O'Donnell J, Mumford AD, Manning RA, Laffan M. Elevation of FVIII: C in venous thromboembolism is persistent and independent of the acute phase response. Thromb Haemost. 2000;83:10–13
  27. Vidal F, Farssac E, Altisent C, Puig L, Gallardo D. Rapid hemophilia A molecular diagnosis by a simple DNA sequencing procedure: identification of 14 novel mutations. Thromb Haemost. 2001;85:580–583

 Portions of this work were presented at the XXII Congress of the International Society on Thrombosis and Haemostasis, Boston, MA, USA, July 16, 2009 (Abstract PP-TH-154).

PII: S0049-3848(10)00229-X

doi: 10.1016/j.thromres.2010.04.004

Thrombosis Research
Volume 126, Issue 2 , Pages 119-123 , August 2010