Thrombosis Research
Volume 126, Issue 2 , Pages e152-e153 , August 2010

Automated APTT cycle for the rapid identification of plasma prekallikrein deficiency

  • Anna Rosa Corno

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +39 02 6444 3952; fax: +39 02 6444 3948.
    • CNR Clinical Physiology Institute, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy
    • ,
  • Jonica Campolo

      Affiliations

    • CNR Clinical Physiology Institute, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy
    • ,
  • Rosaria Redaelli

      Affiliations

    • Hemostasis and Thrombosis Unit, Department of Hematology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy
    • ,
  • Teresa Maria Caimi

      Affiliations

    • Hemostasis and Thrombosis Unit, Department of Hematology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy
    • ,
  • Giovanni Mostarda

      Affiliations

    • Hemostasis and Thrombosis Unit, Department of Hematology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy
    • ,
  • Enrica Morra

      Affiliations

    • Hemostasis and Thrombosis Unit, Department of Hematology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy
    • ,
  • Michele Nichelatti

      Affiliations

    • Service of Biostatistics, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore, 3, 20162 Milan, Italy

Received 3 September 2009 ,Revised 2 February 2010 ,Accepted 3 February 2010.

References 

  1. Schmaier AH, McCrae KR. The plasma kallikrein-kinin system: its evolution from contact activation. J Thromb Haemost. 2007;5:2323–2329
  2. van der Meijden PEJ, Munnix ICA, Auger JM, Govers-Riemslag JWP, Cosemans JMEM, Kuijpers MJE, et al. Dual role of collagen in factor XII-dependent thrombus formation. Blood. 2009;114:881–890
  3. Kannemeier C, Shibamiya A, Nakazawa F, Trusheim H, Ruppert C, Markart P, et al. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci. 2007;104:6388–6393
  4. Mϋller F, Renné T. Novel roles for factor XII-driven plasma contact activation system. Curr Opin Hematol. 2008;15:516–521
  5. Shariat-Madar Z, Mahdi F, Schmaier AH. Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator. J Biol Chem. 2002;277:17962–17969
  6. Joseph K, Tholanikunnel BG, Kaplan AP. Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII. Proc Natl Acad Sci. 2002;99:896–900
  7. François D, Trigui N, Leterreux G, Flaujac C, Horellou MH, Mazaux L, et al. Severe prekallikrein deficiencies due to homozygous C529Y mutations. Blood Coagul Fibrinolysis. 2007;18:283–286
  8. Katsuda I, Maruyama F, Ezaki K, Sawamura T, Ichihara Y. A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region. Eur J Haematol. 2007;79:59–68
  9. Abildgaard CF, Harrison J. Fletcher Factor deficiency: family study and detection. Blood. 1974;43:641–644
  10. Asmis LM, Sulzer I, Furlan M, Lämmle B. Prekallikrein deficiency: The characteristic normalization of the severely prolonged aPTT following increased preincubation time is due to autoactivation of factor XII. Thromb Res. 2002;105:463–470
  11. Robert A. Two different incubation times for the Activated Partial Thromboplastin Time (APTT): a new criterion for diagnosis of Lupus Anticoagulant. Thromb Haemost. 1994;71:220–224
  12. Cloherty T, Golden EA, Lind SE. Use of a modified Activated Partial Thromboplastin Time to detect Lupus Anticoagulants. Thromb Res. 1996;83:137–142

PII: S0049-3848(10)00134-9

doi: 10.1016/j.thromres.2010.02.004

Thrombosis Research
Volume 126, Issue 2 , Pages e152-e153 , August 2010

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