Thrombosis Research
Volume 125, Issue 6 , Pages e294-e299 , June 2010

Clinical characteristics and laboratory testing of patients with suspected HIT: A survey on current practice in 11 university hospitals in France

  • Audrey Bidet

      Affiliations

    • Laboratory of Hematology, Hôpital Cardiologique-Haut Lévêque, CHU Bordeaux, France
    • ,
  • Brigitte Tardy Poncet

      Affiliations

    • Department of Hemostasis, EA3065, CHU Saint Etienne, France
    • ,
  • Dominique Desprez

      Affiliations

    • Laboratory of Hematology, CHU Strasbourg, France
    • ,
  • Emmanuel de Maistre

      Affiliations

    • Department of Hemostasis, CHU Dijon, France
    • ,
  • Emilie Presles

      Affiliations

    • Department of Intensive Care Medicine, Inserm CIE3, CHU Saint Etienne, France
    • ,
  • Thomas Lecompte

      Affiliations

    • Department of Hemostasis, CHU Nancy, France
    • ,
  • Cecile Lavenu-Bombled

      Affiliations

    • Laboratory of Hematology, AP-HP, Hôpital Henri Mondor, CHU de Créteil, France
    • ,
  • Marie Genevieve Huisse

      Affiliations

    • Laboratory of Hematology, AP-HP, Groupe Hospitalier Bichat, CHU Paris, France
    • ,
  • Martine Wolf

      Affiliations

    • Laboratory of Hematology, AP-HP, Hôpital Antoine Béclère, CHU Clamart, France
    • ,
  • Pierre Morange

      Affiliations

    • Laboratory of Hematology, CHU Marseille, France
    • ,
  • Evelyne Racadot

      Affiliations

    • Department of Hemostasis, EFS de Bourgogne-Franche Comté, CHU Besançon, France
    • ,
  • Christine Mouton

      Affiliations

    • Laboratory of Hematology, Hôpital Cardiologique-Haut Lévêque, CHU Bordeaux, France
    • ,
  • Lelia GruneBaum

      Affiliations

    • Laboratory of Hematology, CHU Strasbourg, France
    • ,
  • Claire Pouplard

      Affiliations

    • Department of Hemostasis, CHU Tours, France
    • ,
  • Bernard Tardy

      Affiliations

    • Department of Intensive Care Medicine, Inserm CIE3, CHU Saint Etienne, France
    • Corresponding Author InformationCorresponding author. Department of Intensive Care Medicine, Inserm CIE3, CHU Saint Etienne, France.
    • ,
  • for the GEHT-HIT study group

Received 1 October 2009 ,Revised 22 January 2010 ,Accepted 2 February 2010.

References 

  1. Amiral J, Bridey F, Dreyfus M, Vissac A, Fressinaud E. Wolf, M. Meyer, D. Platelet factor 4 complexed to heparin is the target of antibodies generated in heparin induced thrombocytopenia. Thromb Haemost. 1992;68:95–96
  2. Warkentin TE. Heparin induced thrombocytopenia: pathogenesis and management. Brit J Haematol. 2003;121:535–555
  3. Amiral J, Wolf M, Fischer A, Boyer-Neumann C, Vissac A, Meyer D. Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin induced thrombocytopenia. Brit J Haematol. 1996;92:954–959
  4. Tardy-Poncet B, Piot M, Rancon F, Tardy B, Reynaud J, Campos L, et al. Confirmation of the pathogenic role of Ig M and Ig A anti heparin- PF4 antibodies in patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2005;3(S1):310
  5. Greinacher A, Juhl D, Strobel U, Wessel A, Lubenow N, Selleng K, et al. Heparin induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/ heparin antibodies of the IgG, IgM and IgA classes. J Thromb Haemost. 2007;5:1666–1673
  6. Amiral J, Marfaing-Koka A, Wolf M, Alessi MC, Tardy B, Boyer-Neumann C, et al. Presence of antibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin associated thrombocytopenia. Blood. 1996;88:410–416
  7. Martel N, Lee J, Wells PS. Risk for heparin-induced thrombocytopenia with unfractionated heparin and low-molecular-weight heparins. Blood. 2005;105:2710–2715
  8. Lee DH, Warkentin TE. Frequency of heparin induced thrombocytopenia. In:  Warkentin TE,  Greinacher A editor. heparin induced thrombocytopenia. 4th ed.. New York, NY: Informa Healthcare USA; 2007;p. 67–116
  9. Warkentin TE, Greinacher A, Koster A, Linoff AM. Treatment and prevention of heparin induced thrombocytopenia. Chest. 2008;133:340S–380S
  10. Warkentin TE, Kelton JG. Delayed-onset heparin induced thrombocytopenia and thrombosis. Ann Intern Med. 2001;135:502–506
  11. Lillo-Le Louët A, Boutouyrie P, Alhenc-Gelas M, Le Beller C, Gauthier I, Aiach M, et al. Diagnostic score for heparin-induced thrombocytopenia after cardiopulmonary bypass. J Thromb Haemost. 2004;2:1882–1888
  12. Pouplard C, May MA, Regina S, Marchand M, Fusciardi J, Gruel Y. Changes in platelet count after cardiac surgery can effectively predict the development of pathogenic heparin-dependent antibodies. Brit J Haematol. 2005;128:837–841
  13. Price EA, Hayward CPM, Moffat JC, Warkentin TE, Zehnder JL. Laboratory testing for heparin induced thrombocytopenia is inconsistent in North America: A survey of North America specialized coagulation laboratories. Thromb Haemost. 2007;98:1357–1361
  14. Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A. Evaluation of pretest clinical score (4T's) for the diagnosis of heparin induced thrombocytopenia in two clinical settings. J Thromb Haemost. 2006;4:759–765
  15. Fohlen-Walter A, De Maistre E, Mulot A, Marchand-Arvier M, Lecompte T. Does negative heparin-platelet factor 4 enzyme-linked immunosorbent assay effectively exclude heparin-induced thrombocytopenia?. Thromb Haemost. 2003;1:1844–1845
  16. Greinacher A, Juhl D, Strobel U, Wessel A, Lubenow N, Selleng K, et al. Heparin induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/ heparin antibodies of the IgG, IgM and IgA classes. Thromb Haemost. 2007;5:1666–1673
  17. Warkentin TE, Sheppard JO, Moore JC, Moore KM, Sigouin CS, Kelton JG. Laboratory testing for antibodies that cause heparin induced thrombocytopenia: How much class do we need?. J Lab Clin Med. 2005;146:341–346
  18. Elalamy I, Tardy-Poncet B, Mulot A, de Maistre E, Pouplard C, Nguyen P, et al. Risk factors for unfavourable clinical outcome in patients with documented heparin induced thrombocytopenia. Thromb Res. 2009;124:554–559
  19. Conférence d'experts . Heparin induced thrombocytopenia. Ann Fr Anesth Réanim. 2003;22:150–159

PII: S0049-3848(10)00130-1

doi: 10.1016/j.thromres.2010.02.003

Thrombosis Research
Volume 125, Issue 6 , Pages e294-e299 , June 2010

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