Thrombosis Research
Volume 125 , Pages S74-S77 , April 2010

Wound healing in hemophilia B mice and low tissue factor mice

  • Dougald M. Monroe

      Affiliations

    • School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    • Corresponding Author InformationCorresponding author. University of North Carolina at Chapel Hill, School of Medicine, Division of Hematology/Oncology, 932 Mary Ellen Jones Bldg., Chapel Hill, NC 27599-7035. Tel.: +1 919 966 3312; fax: +1 919 966 7639.
    • ,
  • Nigel Mackman

      Affiliations

    • School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    • ,
  • Maureane Hoffman

      Affiliations

    • Department of Pathology, Duke University, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA

References 

  1. Sun J, Hakobyan N, Valentino LA, Feldman BL, Samulski RJ, Monahan PE. Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX. Blood. 2008;112:4532–4541
  2. Lafeber FPJG, Miossec P, Valentino LA. Physiopathology of haemophilic arthropathy. Haemophilia. 2008;14(Suppl 4):3–9
  3. Witte MB, Barbul A. General principles of wound healing. Surg Clin North Am. 1997;77:509–528
  4. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738–746
  5. Laurens N, Koolwijk P, de Maat MPM. Fibrin structure and wound healing. J Thromb Haemost. 2006;4:932–939
  6. Drew AF, Liu H, Davidson JM, Daugherty CC, Degen JL. Wound-healing defects in mice lacking fibrinogen. Blood. 2001;97:3691–3698
  7. Inbal A, Lubetsky A, Krapp T, Castel D, Shaish A, Dickneitte G, et al. Impaired wound healing in factor XIII deficient mice. Thromb Haemost. 2005;94:432–437
  8. Cox S, Cole M, Tawil B. Behavior of human dermal fibroblasts in three-dimensional fibrin clots: dependence on fibrinogen and thrombin concentration. Tissue Eng. 2004;10:942–954
  9. Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, et al. Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med. 1996;2:287–292
  10. Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev. 2007;21:131–142
  11. Dugina TN, Kiseleva EV, Chistov IV, Umarova BA, Strukova SM. Receptors of the PAR family as a link between blood coagulation and inflammation. Biochemistry (Mosc). 2002;67:65–74
  12. Landis RC. Protease activated receptors: clinical relevance to hemostasis and inflammation. Hematol Oncol Clin North Am. 2007;21:103–113
  13. Bar-Shavit R, Kahn A, Fenton JW, Wilner GD. Chemotactic response of monocytes to thrombin. J Cell Biol. 1983;96:282–285
  14. Dawes KE, Gray AJ, Laurent GJ. Thrombin stimulates fibroblast chemotaxis and replication. Eur J Cell Biol. 1993;61:126–130
  15. Norfleet AM, Bergmann JS, Carney DH. Thrombin peptide, TP508, stimulates angiogenic responses in animal models of dermal wound healing, in chick chorioallantoic membranes, and in cultured human aortic and microvascular endothelial cells. Gen Pharmacol. 2000;35:249–254
  16. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057–1068
  17. Connolly AJ, Suh DY, Hunt TK, Coughlin SR. Mice lacking the thrombin receptor, PAR1, have normal skin wound healing. Am J Pathol. 1997;151:1199–1204
  18. Major CD, Santulli RJ, Derian CK, Andrade-Gordon P. Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout mice. Arterioscler Thromb Vasc Biol. 2003;23:931–939
  19. Strukova SM, Dugina TN, Chistov IV, Lange M, Markvicheva EA, Kuptsova S, et al. Immobilized thrombin receptor agonist peptide accelerates wound healing in mice. Clin Appl Thromb Hemost. 2001;7:325–329
  20. Lin HF, Maeda N, Smithies O, Straight DL, Stafford DW. A coagulation factor IX-deficient mouse model for human hemophilia B. Blood. 1997;90:3962–3966
  21. Whinna HC, Monroe DM. A novel murine hemostasis model: studies on recombinant factor VIIa and NN1731. J Thromb Haemost. 2009;7:PP-MO-392
  22. Hoffman M, Harger A, Lenkowski A, Hedner U, Roberts HR, Monroe DM. Cutaneous wound healing is impaired in hemophilia B. Blood. 2006;108:3053–3060
  23. McDonald A, Hoffman M, Hedner U, Roberts HR, Monroe DM. Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B. J Thromb Haemost. 2007;5:1577–1583
  24. Monroe DM, Key NS. The tissue factor-factor VIIa complex: procoagulant activity, regulation, and multitasking. J Thromb Haemost. 2007;5:1097–1105
  25. Chen J, Kasper M, Heck T, Nakagawa K, Humpert PM, Bai L, et al. Tissue factor as a link between wounding and tissue repair. Diabetes. 2005;54:2143–2154
  26. McDonald AG, Yang K, Roberts HR, Monroe DM, Hoffman M. Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. Blood. 2008;111:2046–2048
  27. Parry GC, Erlich JH, Carmeliet P, Luther T, Mackman N. Low levels of tissue factor are compatible with development and hemostasis in mice. J Clin Invest. 1998;101:560–569

PII: S0049-3848(10)00096-4

doi: 10.1016/j.thromres.2010.01.043

Thrombosis Research
Volume 125 , Pages S74-S77 , April 2010

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