Cellular sources of tissue factor in endotoxemia and sepsis

Abstract 

Sepsis is a systemic host response to infection by pathogenic microorganisms. Activation of the coagulation cascade during endotoxemia and sepsis leads to disseminated intravascular coagulation. This review focuses on tissue factor expression by hematopoietic and non-hematopoietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis.

Abbreviations: TF, tissue factor, FVII, factor VII, DIC, disseminated intravascular coagulation, LPS, lipopolysaccharide, TAT, thrombin-antithrombin, TFPI, tissue factor pathway inhibitor, ECs, endothelial cells

Keywords: Tissue factor, Cell type, Sepsis, Endotoxemia, Disseminated intravascular coagulation