Cellular sources of tissue factor in endotoxemia and sepsis

published online 25 February 2010.

Abstract

Sepsis is a systemic host response to infection by pathogenic microorganisms. Activation of the coagulation cascade during endotoxemia and sepsis leads to disseminated intravascular coagulation. This review focuses on tissue factor expression by hematopoietic and non-hematopoietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis.

Abbreviations: TF, tissue factor, FVII, factor VII, DIC, disseminated intravascular coagulation, LPS, lipopolysaccharide, TAT, thrombin-antithrombin, TFPI, tissue factor pathway inhibitor, ECs, endothelial cells

Keywords: Tissue factor, Cell type, Sepsis, Endotoxemia, Disseminated intravascular coagulation

Hematology and Oncology Division, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA

Corresponding author. Tel.: +1 919 843 3961; fax: +1 919 843 4896.

PII: S0049-3848(10)00095-2

doi:10.1016/j.thromres.2010.01.042

23 of 25