Thrombosis Research
Volume 125, Supplement 1 , Pages S67-S69, April 2010

Tissue factor microparticles and haemophilia

  • Peter L. Gross

      Affiliations

    • Corresponding Author InformationCorresponding author. Thrombosis and Atherosclerosis Research Institute, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2. Tel.: +1 905 521 2100x40779; fax: +1 905 575 2646.
    • ,
  • Nima Vaezzadeh

Department of Medicine, McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada L8L 2X2

published online 22 February 2010.

Abstract 

Treatment choices for haemophilia patients with inhibitors are suboptimal. Tissue factor-bearing microparticles home to thrombi in a cell adhesion molecule-dependent fashion. Their potential utility as a procoagulant is discussed along with the challenges of evaluating this approach in mouse models of haemophilia.

Abbreviations: TF, tissue factor, PSGL-1, P-selectin glycoprotein ligand-1

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PII: S0049-3848(10)00094-0

doi:10.1016/j.thromres.2010.01.041

Thrombosis Research
Volume 125, Supplement 1 , Pages S67-S69, April 2010

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