« Previous
Next »
Thrombosis Research
Volume 125
, Pages S60-S62
, April 2010
Long-term expression of canine FVIIa in hemophilic dogs
References
- . Inhibitor development in patients with hemophilia: an overview. Semin Hematol. 2006;43(2 Suppl 4):S1–S2
- . Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII. J Clin Invest. 2004;7:1025–1031
- . Species specificity of tissue thromboplastin. Haemostasis. 1984;14:440–444
- . Tissue factor activity of normal and neoplastic cells: quantitation and species specificity. J Natl Cancer Inst. 1983;70:551–557
- Characterization of recombinant murine factor VIIa and recombinant murine tissue factor: a human-murine species compatibility study. Thromb Res. 2005;116:75–85
- Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality. J Clin Invest. 2008;118:1825–1834
- Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant hemophilia B dogs. Blood. 2003;102:4393–4398
- Preclinical pharmacology of albumin-free B-domain deleted recombinant factor VIII. Semin Thromb Hemost. 2002;28:269–272
- . Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease. Proc Natl Acad Sci U S A. 1989;86:1382–1386
- Purified human factor VIII procoagulant protein: comparative hemostatic response after infusions into hemophilic and von Willebrand disease dogs. Proc Natl Acad Sci U S A. 1985;82:8752–8756
- . A new high-potency glycine-precipitated antihemophilic factor (AHF) concentrate. Treatment of classical hemophilia and hemophilia with inhibitors. JAMA. 1968;205:613–617
- Recombinant human factor IX: replacement therapy, prophylaxis, and pharmacokinetics in canine hemophilia B. Blood. 1996;88:2603–2610
- Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs. Blood. 2006;108:107–115
- Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy. Blood. 2002;99:2670–2676
- Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice. Hum Gene Ther. 2006;17:427–439
- Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy. Blood. 2005;105:3079–3086
- A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost. 2006;4:2616–2622
- Successful treatment of canine hemophilia by continuous expression of canine FVIIa. Blood. 2009;113:3682–3689
- Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver. Blood. 2006;107:2653–2661
- Optimization of self-complementary AAV vectors for liver-directed expression results in sustained correction of hemophilia B at low vector dose. Mol Ther. 2008;16:280–289
- . Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity. J Biol Chem. 2001;276:29195–29199
- . Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement. Biochem J. 2004;379:497–503
- . Mutagenesis of the gamma-carboxyglutamic acid domain of human factor VII to generate maximum enhancement of the membrane contact site. J Biol Chem. 2003;278:8363–8369
- . Elevated function of blood clotting factor VIIa mutants that have enhanced affinity for membranes. Behavior in a diffusion-limited reaction. J Biol Chem. 2001;276:39825–39831
- . rFVIIa and a new enhanced rFVIIa-analogue, NN1731, reduce bleeding in clopidogrel-treated and in thrombocytopenic rats. J Thromb Haemost. 2009;7:651–657
- . Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A. Blood. 2003;102:3615–3620
- . Evaluation of the safety and pharmacokinetics of a fast-acting recombinant FVIIa analogue, NN1731, in healthy male subjects. J Thromb Haemost. 2009;7:299–305
PII: S0049-3848(10)00093-9
doi: 10.1016/j.thromres.2010.01.040
© 2010 Elsevier Ltd. All rights reserved.
« Previous
Next »
Thrombosis Research
Volume 125
, Pages S60-S62
, April 2010
