Thrombosis Research
Volume 125 , Pages S46-S48 , April 2010

Formation of procoagulant microparticles and properties

  • Jean-Marie Freyssinet

      Affiliations

    • Corresponding Author InformationCorresponding author. Institut d'Hématologie & Immunologie, Faculté de Médecine, Université de Strasbourg, 4 rue Kirschleger F-67085 Strasbourg, France. Tel.: +33 3 68 85 39 85; fax: +33 3 68 85 40 16.
    • ,
  • Florence Toti

References 

  1. Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9:581–593
  2. Combes V, Simon AC, Grau GE, Arnoux D, Camoin L, Sabatier F, et al. In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. J Clin Invest. 1999;104:93–102
  3. VanWijk MJ, VanBavel E, Sturk A, Nieuwland R. Microparticles in cardiovascular diseases. Cardiovasc Res. 2003;59:277–287
  4. Morel O, Toti F, Hugel B, Bakouboula B, Camoin-Jau L, Dignat-George F, et al. Procoagulant microparticles: disrupting the vascular homeostasis equation?. Arterioscler Thromb Vasc Biol. 2006;26:2594–2604
  5. Manly DA, Wang J, Glover SL, Kasthuri R, Liebman HA, Key NS, et al. Increased microparticle tissue factor activity in cancer patients with Venous Thromboembolism. Thromb Res. 2009;Electronic publication ahead of print
  6. Doeuvre L, Plawinski L, Toti F, Angles-Cano E. Cell-derived microparticles: a new challenge in neuroscience. J Neurochem. 2009;110:457–468
  7. Mackman N, Tilley RE, Key NS. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol. 2007;27:1687–1693
  8. Toti F, Satta N, Fressinaud E, Meyer D, Freyssinet JM. Scott syndrome, characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic complications, is an inherited disorder. Blood. 1996;87:1409–1415
  9. Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood. 1997;89:1121–1132
  10. Hugel B, Martinez MC, Kunzelmann C, Freyssinet JM. Membrane microparticles: two sides of the coin. Physiology (Bethesda). 2005;20:22–27
  11. Zwaal RF, Comfurius P, Bevers EM. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci. 2005;62:971–988
  12. Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Soding J. Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors. Bioinformatics. 2009;25:159–162
  13. Hamon Y, Broccardo C, Chambenoit O, Luciani MF, Toti F, Chaslin S, et al. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol. 2000;2:399–406
  14. Albrecht C, McVey JH, Elliott JI, Sardini A, Kasza I, Mumford AD, et al. A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome. Blood. 2005;106:542–549
  15. Brooks MB, Catalfamo JL, Etter K, Brisbin A, Bustamante CD. Exclusion of ABCA-1 as a candidate gene for canine Scott syndrome. J Thromb Haemost. 2008;6:1608–1610
  16. Senzel L, Gnatenko DV, Bahou WF. The platelet proteome. Curr Opin Hematol. 2009;16:329–333
  17. Del Conde I, Shrimpton CN, Thiagarajan P, Lopez JA. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood. 2005;106:1605–1611
  18. Leon C, Alex M, Klocke A, Morgenstern E, Moosbauer C, Eckly A, et al. Platelet ADP receptors contribute to the initiation of intravascular coagulation. Blood. 2004;103:594–600
  19. Kasthuri RS, Taubman MB, Mackman N. Role of tissue factor in cancer. J Clin Oncol. 2009;27:4834–4838
  20. Freyssinet JM, Toti F. Membrane microparticle determination: at least seeing what's being sized!. J Thromb Haemost. 2010;8:311–314

PII: S0049-3848(10)00089-7

doi: 10.1016/j.thromres.2010.01.036

Thrombosis Research
Volume 125 , Pages S46-S48 , April 2010

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