Thrombosis Research
Volume 125 , Pages S19-S22 , April 2010

Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor

  • Usha R. Pendurthi

      Affiliations

    • Corresponding Author InformationCorresponding author. Center for Biomedical Research, The University of Texas Health Science Center, 11937 US Highway 271, Tyler, TX 75708, United States. Tel.: +1 903 877 7342; fax: +1 903 877 7426.
    • ,
  • L. Vijaya Mohan Rao

References 

  1. Rodgers GM, Broze GJ, Shuman MA. The number of receptors for factor VII correlates with the ability of cultured cells to initiate coagulation. Blood. 1984;63:434–438
  2. Reuning U, Preissner KT, Muller-Berghaus G. Two independent binding sites on monolayers of human umbilical vein endothelial cells are responsible for interaction with coagulation factor VII and factor VIIa. Thromb Haemost. 1993;69:197–204
  3. Ghosh S, Pendurthi UR, Steinoe A, Esmon CT, Rao LV. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem. 2007;282:11849–11857
  4. Schuepbach RA, Riewald M. Coagulation factor Xa cleaves PAR1 and mediates signaling dependent on binding to the endothelial protein C receptor. J Thromb Haemost 2010;8:379–88.
  5. Ho G, Toomey JR, Broze GJ, Schwartz AL. Receptor-mediated endocytosis of coagulation factor Xa requires cell surface-bound tissue factor pathway inhibitor. J Biol Chem. 1996;271:9497–9502
  6. Bhattacharjee G, Ahamed J, Pawlinski R, et al. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res. 2008;102:457–464
  7. Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K, Esmon CT. The endothelial cell protein c receptor. J Biol Chem. 1996;271:17499–17503
  8. Laszik Z, Mitro A, Taylor FB, Ferrell G, Esmon CT. Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. Circulation. 1997;96:3633–3640
  9. Galligan L, Livingstone W, Volkov Y, et al. Characterization of protein C receptor expression in monocytes. Br J Haematol. 2001;115:408–414
  10. Balazs AB, Fabian AJ, Esmon CT, Mulligan RC. Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. Blood. 2006;107:2317–2321
  11. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A. 1996;93:10212–10216
  12. Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by protein C pathway. Science. 2002;296:1880–1882
  13. Cheng T, Liu D, Griffin JH, et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003;9:338–342
  14. Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood. 2005;105:3178–3184
  15. Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin SR. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005;280:13122–13128
  16. O'Brien LA, Richardson MA, Mehrbod SF, et al. Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an. Arterioscler Thromb Vasc Biol. 2007;27:2634–2641
  17. Preston RJ, Ajzner E, Razzari C, et al. Multifunctional specificity of the protein C/activated protein C Gla domain. J Biol Chem. 2006;281:28850–28857
  18. Lopez-Sagaseta J, Montes R, Puy C, Diez N, Fukudome K, Hermida J. Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity. J Thromb Haemost. 2007;5:1817–1824
  19. Liaw PC, Mather T, Oganesyan N, Ferrell GL, Esmon CT. Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor. J Biol Chem. 2001;276:8364–8370
  20. Fukudome K, Esmon CT. Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). J Biol Chem. 1995;270:5571–5577
  21. Li W, Zheng X, Gu J, et al. Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost. 2005;3:1351–1359
  22. Nayak RC, Sen P, Ghosh S, et al. Endothelial cell protein C receptor cellular localization and trafficking. Blood. 2009;114:1974–1986
  23. Gopalakrishnan R, Hedner U, Ghosh S, et al. Bio-distribution of pharmacologically administered rFVIIa. J Thromb Haemost 2010;8:301–10.
  24. Ireland HA, Cooper JA, Drenos F, et al. FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men. Arterioscler Thromb Vasc Biol. 2009;29:1968–1974
  25. Esmon CT. Dimorphisms in the membrane-spanning domain of EPCR impact systemic coagulation. Arterioscler Thromb Vasc Biol. 2009;29:1712–1713
  26. Bae JS, Yang L, Manithody C, Rezaie AR. The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood. 2007;110:3909–3916
  27. Rao LVM, Pendurthi UR. Tissue factor-factor VIIa signaling. Arterioscler Thromb Vasc Biol. 2005;25:47–56
  28. Pendurthi UR, Allen KE, Ezban M, Rao LVM. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VII.tissue factor-induced signal transduction. J Biol Chem. 2000;275:14632–14641
  29. Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab. 2009;29:25–33
  30. Hedner U, Ezban M. Tissue factor and factor VIIa as therapeutic targets in disorders of hemostasis. Annu Rev Med. 2008;59:29–41
  31. Roberts HR, Monroe DM, White GC. The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood. 2004;104:3858–3864

PII: S0049-3848(10)00079-4

doi: 10.1016/j.thromres.2010.01.026

Thrombosis Research
Volume 125 , Pages S19-S22 , April 2010

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