Thrombosis Research
Volume 125 , Pages S13-S15 , April 2010

The interaction of recombinant factor VIIa with platelet glycoprotein Ib

  • Ton Lisman

      Affiliations

    • Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    • Corresponding Author InformationCorresponding author. Surgical Research Laboratory, BA 44, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands. Tel.: +31 50 3619028; fax: +31 50 363 2796.
    • ,
  • Philip G. de Groot

      Affiliations

    • Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands

References 

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  3. Monroe DM, Hoffman M, Roberts HR. Platelets and thrombin generation. Arterioscler Thromb Vasc Biol. 2002;22:1381–1389
  4. Lisman T. Factor XI binding to platelets: glycoprotein Ib alpha has an accomplice. Arterioscler Thromb Vasc Biol. 2009;29:1409–1410
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  6. Weeterings C, de Groot PG, Adelmeijer J, Lisman T. The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface. Blood. 2008;112:3227–3233
  7. Weeterings C, de Groot PG, Lisman T. Glycoprotein Ib-alpha modulates factor IXa-mediated factor Xa-generation on the activated platelet surface. J Thromb Haemost. 2009;7:126;PP-MO
  8. Baglia FA, Badellino KO, Li CQ, Lopez JA, Walsh PN. Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin. J Biol Chem. 2002;277:1662–1668
  9. Bradford HN, Pixley RA, Colman RW. Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation. J Biol Chem. 2000;275:22756–22763
  10. Joseph K, Nakazawa Y, Bahou WF, Ghebrehiwet B, Kaplan AP. Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen. Mol Med. 1999;5:555–563
  11. De Marco L, Mazzucato M, Masotti A, Ruggeri ZM. Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha. J Biol Chem. 1994;269:6478–6484
  12. White TC, Berny MA, Tucker EI, Urbanus RT, de Groot PG, Fernandez JA, et al. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. J Thromb Haemost. 2008;6:995–1002
  13. Rawala-Sheikh R, Ahmad SS, Monroe DM, Roberts HR, Walsh PN. Role of gamma-carboxyglutamic acid residues in the binding of factor IXa to platelets and in factor-X activation. Blood. 1992;79:398–405
  14. Simon DI, Chen Z, Xu H, Li CQ, Dong J, McIntire LV, et al. Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med. 2000;192:193–204
  15. Romo GM, Dong JF, Schade AJ, Gardiner EE, Kansas GS, Li CQ, et al. The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J Exp Med. 1999;190:803–814
  16. Agbanyo FR, Sixma JJ, de Groot PG, Languino LR, Plow EF. Thrombospondin-platelet interactions. Role of divalent cations, wall shear rate, and platelet membrane glycoproteins. J Clin Invest. 1993;92:288–296
  17. Pennings MT, Derksen RH, van Lummel M, Adelmeijer J, VanHoorelbeke K, Urbanus RT, et al. Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibalpha and apolipoprotein E receptor 2'. J Thromb Haemost. 2007;5:369–377
  18. White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, et al. Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol. 2009;29:1602–1607
  19. ten Cate H, Bauer KA, Levi M, Edgington TS, Sublett RD, Barzegar S, et al. The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor. J Clin Invest. 1993;92:1207–1212
  20. Lisman T, de Groot PG. Mechanism of action of recombinant factor VIIa. J Thromb Haemost. 2003;1:1138–1139
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PII: S0049-3848(10)00077-0

doi: 10.1016/j.thromres.2010.01.024

Thrombosis Research
Volume 125 , Pages S13-S15 , April 2010

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