Thrombosis Research
Volume 125, Issue 5 , Pages e214-e221 , May 2010

Role of plasminogen in macrophage accumulation during liver repair

  • Naoyuki Kawao

      Affiliations

    • Department of Physiology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan
  • ,
  • Nobuo Nagai

      Affiliations

    • Department of Physiology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan
  • ,
  • Kiyotaka Okada

      Affiliations

    • Department of Physiology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan
  • ,
  • Katsumi Okumoto

      Affiliations

    • Center for Morphological Analyses in Central Research Facilities, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan
  • ,
  • Shigeru Ueshima

      Affiliations

    • Department of Physiology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan
    • Department of Food Science and Nutrition, Kinki University School of Agriculture, 3327-204 Nakamachi, Nara 631-8505, Japan
  • ,
  • Osamu Matsuo

      Affiliations

    • Department of Physiology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 72 366 0221x3165; fax: +81 72 366 0206.

Received 11 August 2009 ,Revised 17 November 2009 ,Accepted 9 December 2009.

References 

  1. Bilzer M, Gerbes AL. Preservation injury of the liver: mechanisms and novel therapeutic strategies. J Hepatol. 2000;32:508–515
  2. Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology. 2003;125:1246–1257
  3. Wallace K, Burt AD, Wright MC. Liver fibrosis. Biochem J. 2008;411:1–18
  4. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341:738–746
  5. Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest. 2005;115:56–65
  6. Castellino FJ, Ploplis VA. Structure and function of the plasminogen/plasmin system. Thromb Haemost. 2005;93:647–654
  7. Busuttil SJ, Ploplis VA, Castellino FJ, Tang L, Eaton JW, Plow EF. A central role for plasminogen in the inflammatory response to biomaterials. J Thromb Haemost. 2004;2:1798–1805
  8. Ploplis VA, French EL, Carmeliet P, Collen D, Plow EF. Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice. Blood. 1998;91:2005–2009
  9. Gong Y, Hart E, Shchurin A, Hoover-Plow J. Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice. J Clin Invest. 2008;118:3012–3024
  10. Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol. 2007;8:221–233
  11. Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, et al. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc Natl Acad Sci U S A. 1999;96:15143–15148
  12. Pohl JF, Melin-Aldana H, Sabla G, Degen JL, Bezerra JA. Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury. Am J Pathol. 2001;159:2179–2186
  13. Okada K, Ueshima S, Imano M, Kataoka K, Matsuo O. The regulation of liver regeneration by the plasmin/alpha 2-antiplasmin system. J Hepatol. 2004;40:110–116
  14. Kawao N, Okada K, Kawata S, Okamoto C, Tsuritani M, Ueshima S, et al. Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes. Biochim Biophys Acta. 2007;1773:718–727
  15. Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, et al. Binding of plasminogen to hepatocytes isolated from injured mice liver and nonparenchymal cell-dependent proliferation of hepatocytes. Blood Coagul Fibrinolysis. 2008;19:503–511
  16. Shanmukhappa K, Matte U, Degen JL, Bezerra JA. Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem. 2009;284:12917–12923
  17. Ploplis VA, Carmeliet P, Vazirzadeh S, Van Vlaenderen I, Moons L, Plow EF, et al. Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation. 1995;92:2585–2593
  18. Jha S, Calvert JW, Duranski MR, Ramachandran A, Lefer DJ. Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. Am J Physiol Heart Circ Physiol. 2008;295:H801–H806
  19. Suzuki Y, Nagai N, Umemura K, Collen D, Lijnen HR. Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice. J Thromb Haemost. 2007;5:1732–1739
  20. Das R, Burke T, Plow EF. Histone H2B as a functionally important plasminogen receptor on macrophages. Blood. 2007;110:3763–3772
  21. Miles LA, Dahlberg CM, Plescia J, Felez J, Kato K, Plow EF. Role of cell-surface lysines in plasminogen binding to cells: identification of alpha-enolase as a candidate plasminogen receptor. Biochemistry. 1991;30:1682–1691
  22. Falcone DJ, Borth W, Khan KM, Hajjar KA. Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II. Blood. 2001;97:777–784
  23. Burysek L, Syrovets T, Simmet T. The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways. J Biol Chem. 2002;277:33509–33517
  24. Sheehan JJ, Zhou C, Gravanis I, Rogove AD, Wu YP, Bogenhagen DF, et al. Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice. J Neurosci. 2007;27:1738–1745
  25. Richardson DL, Pepper DS, Kay AB. Chemotaxis for human monocytes by fibrinogen-derived peptides. Br J Haematol. 1976;32:507–513
  26. Lijnen HR, Silence J, Lemmens G, Frederix L, Collen D. Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen/plasmin system. Thromb Haemost. 1998;79:1171–1176
  27. Olle EW, Ren X, McClintock SD, Warner RL, Deogracias MP, Johnson KJ, et al. Matrix metalloproteinase-9 is an important factor in hepatic regeneration after partial hepatectomy in mice. Hepatology. 2006;44:540–549

PII: S0049-3848(09)00561-1

doi: 10.1016/j.thromres.2009.12.009

Thrombosis Research
Volume 125, Issue 5 , Pages e214-e221 , May 2010