Thrombosis Research
Volume 126, Issue 1 , Pages 18-23 , July 2010

Evaluation of modified non-overt DIC criteria on the prediction of poor outcome in patients with sepsis

  • D. Oh

      Affiliations

    • Department of Internal Medicine, College of Medicine, Pochon CHA University, Sungnam, Korea
    • Institute for Clinical Research, College of Medicine, Pochon CHA University, Sungnam, Korea
    • Corresponding Author InformationCorresponding author. Department of Internal Medicine, College of Medicine, Pochon CHA University, 351 Yatap-dong, Bundang-gu, Sungnam 463-712, Korea. Tel.: +82 31 780 5217; fax: +82 31 780 5208.
    • ,
  • M.J. Jang

      Affiliations

    • Department of Internal Medicine, College of Medicine, Pochon CHA University, Sungnam, Korea
    • ,
  • S.J. Lee

      Affiliations

    • Institute for Clinical Research, College of Medicine, Pochon CHA University, Sungnam, Korea
    • ,
  • S.Y. Chong

      Affiliations

    • Department of Internal Medicine, College of Medicine, Pochon CHA University, Sungnam, Korea
    • ,
  • M.S. Kang

      Affiliations

    • Department of Laboratory Medicine, College of Medicine, Pochon CHA University, Sungnam, Korea
    • ,
  • H. Wada

      Affiliations

    • Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu-city, Japan

Received 25 August 2009 ,Revised 9 November 2009 ,Accepted 2 December 2009.

References 

  1. Taylor FB, Toh CH, Hoots WK, Wada H, Levi M. Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86:1327–1330
  2. Levi M, ten Cate H. Disseminated intravascular coagulation. N Engl J Med. 1999;341:586–592
  3. Gando S, Kameue T, Nanzaki S, Nakanishi Y. Disseminated intravascular coagulation is a frequent complication of systemic inflammatory response syndrome. Thromb Haemost. 1996;75:224–228
  4. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut J-F, Lopez-Rodriguez A, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699–709
  5. Warren BL, Eid A, Singer P, Pillay SS, Carl P, Novak I, et al. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA. 2001;286:1869–1878
  6. Dhainaut JF, Yan SB, Joyce DE, Pettilä V, Basson B, Brandt JT, et al. Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. J Thromb Haemost. 2004;2:1924–1933
  7. Kienast J, Juers M, Wiedermann CJ, Hoffmann JN, Ostermann H, Strauss R, et al. Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation. J Thromb Haemost. 2005;4:90–97
  8. Angstwurm MW, Dempfle CE, Spannagl M. New disseminated intravascular coagulation score: A useful tool to predict mortality in comparison with Acute Physiology and Chronic Health Evaluation II and Logistic Organ Dysfunction scores. Crit Care Med. 2006;34:314–320
  9. Okabayashi K, Wada H, Ohta S, Shiku H, Nobori T, Maruyama K. Hemostatic markers and Sepsis-related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit. Am J Hematol. 2004;76:225–229
  10. Dematte D'Amico JE, Donnelly HK, Mutlu GM, Feinglass J, Jovanovic BD, Ndukwu IM. Risk assessment for inpatient survival in the long-term acute care setting after prolonged critical illness. Chest. 2003;124:1039–1045
  11. Bone RC, Balk RA, Cerra FB. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644–1655
  12. Toh CH, Downey C. Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation. Blood Coagul Fibrinolysis. 2005;16:69–74
  13. Asakura H, Wada H, Okamoto K, Iba T, Uchiyama T, Eguchi Y, et al. Evaluation of haemostatic molecular markers for diagnosis of disseminated intravascular coagulation in patients with infections. Thromb Haemost. 2006;95:282–287
  14. Kobayashi A, Matsuda Y, Mitani M, Makino Y, Ohta H. Assessment of the Usefulness of Antithrombin-III in the Management of Disseminated Intravascular Coagulation in Obstetrically Ill Patients. Clin Appl Thromb Hemost. 2009;[Electronic publication ahead of print]
  15. Voves C, Wuillemin WA, Zeerleder S. International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients. Blood Coagul Fibrinolysis. 2006;17:445–451
  16. Wada H, Sakuragawa N, Mori Y, Takagi M, Nakasaki T, Shimura M, et al. Hemostatic molecular markers before the onset of disseminated intravascular coagulation. Am J Hematol. 1999;60:273–278
  17. Wada H, Minamikawa K, Wakita Y, Nakase T, Kaneko T, Ohiwa M, et al. Hemostatic study before onset of disseminated intravascular coagulation. Am J Hematol. 1993;43:190–194
  18. Wada H, Wakita Y, Nakase T, Shimura M, Hiyoyama K, Nagaya S, et al. Outcome of disseminated intravascular coagulation in relation to the score when treatment was begun. Mie DIC Study Group. Thromb Haemost. 1995;74:848–852
  19. Kinasewitz GT, Zein JG, Lee GL, Nazir SA, Taylor FB. Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis. Crit Care Med. 2005;33:2214–2221
  20. Iba T, Gando S, Murata A, Kushimoto S, Saitoh D, Eguchi Y, et al. Japanese Association for Acute Medicine Disseminated Intravascular Coagulation Study Group.Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers. J Trauma. 2007;63:1093–1098

PII: S0049-3848(09)00560-X

doi: 10.1016/j.thromres.2009.12.008

Thrombosis Research
Volume 126, Issue 1 , Pages 18-23 , July 2010

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