Thrombosis Research
Volume 125, Issue 3 , Pages 253-256 , March 2010

Presence of Integrin alpha(IIb)beta3 in early gestation human trophoblasts: Possible involvement of fibrin as a matrix ligand

  • Ayelet Snir

      Affiliations

    • Thrombosis and Hemostasis Unit, Dept. of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus P.O.B 9602, Haifa, 31096, Israel
    • ,
  • Benjamin Brenner

      Affiliations

    • Thrombosis and Hemostasis Unit, Dept. of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus P.O.B 9602, Haifa, 31096, Israel
    • ,
  • Baram. Paz

      Affiliations

    • Dept of Gynecology and Obstetrics, Bnei Zion Medical Center, Haifa, 31096, Israel
    • Bruce Rappaport Faculty of Medicine, Technion, Haifa, 31096, Israel
    • ,
  • Naomi Lanir

      Affiliations

    • Thrombosis and Hemostasis Unit, Dept. of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus P.O.B 9602, Haifa, 31096, Israel
    • Corresponding Author InformationCorresponding author. Laboratory of Hematology , Rambam Health Care Campus, Haifa, Israel 31096. Tel.: +972 4 8542217, +972 502062582 (mobile); fax: +972 4 8543636.

Received 6 September 2009 ,Revised 5 November 2009 ,Accepted 23 November 2009.

References 

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  2. Zhou Y, Fisher SJ, Janatpour M, Genbacev O, Dejana E, Wheelock M, et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?. J Clin Invest. 1997;99:2139–2151
  3. Damsky CH, Fitzgerald ML, Fisher SJ. Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo. J Clin Invest. 1992;89(1):210–222
  4. Bischof P, Irminger-Finger I. The human cytotrophoblastic cell, a mononuclear chameleon. Int J Biochem Cell Biol. 2005;37(1):1–16
  5. Rout UK, Wang J, Paria BC, Armant DR. Alpha5beta1, alphaVbeta3 and the platelet-associated integrin alphaIIbbeta3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cells. Dev Biol. 2004;268:135–151
  6. Chen YQ, Trikha M, Gao X, Bazaz R, Porter AT, Timar J, et al. Ectopic expression of platelet alphaIIb beta3 in tumor cells from various species and histological origin. Int J Cancer. 1997;72:647–648
  7. Du XP, Plow EF, Frelinger AL, O'Toole TE, Loftus JC, Ginsberg MH. Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Cell. 1991;65(3):409–416
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  12. Lanir N, Aharon A, Brenner B. Procoagulant and anticoagulant mechanisms in human placenta. Semin Thromb Hemost. 2003;29:175–184
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  16. Schultz JF, Mayernik L, Rout UK, Armant DR. Integrin trafficking regulates adhesion to fibronectin during differentiation of mouse peri-implantation blastocysts. Dev Genet. 1997;21(1):31–43
  17. Aharon A, Tamari T, Brenner B. Monocytes derived microparticles and exosomes induce apoptotoc and procoagulant effects in endothelial cells. Thromb Haemost. 2008;100:878–885
  18. Iwaki T, Castellino FJ. Maternal fibrinogen is necessary for embryonic development. Curr Drug Targets. 2005;6:535–539
  19. Iwaki T, M.J. Sandoval –Cooper, Paiva M, Kobayashi T, Castellino FJ, Ploplis VA. Fibrinogen stabilizes placenta maternal attachment during embryonic development in the mouse. Am J Pathol. 2002;160:1021–1034
  20. Asahina T, Kobayashi T, Okada Y, Goto J, Terao T. Maternal blood coagulation factor XIII is associated with the development of cytotrophoblastic shell. Placenta. 2000;21:3888-393
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  22. Leticee N, Kaplan C, Lemory D. Pregnancy in mother with Glanzmann's thrombasthenia and isoantibody agianst GPIIbIIIa: Is there a foetal risk?. Eur J Obstet Gynecol Reprod Biol. 2005;121:139–142

☆ The study was presented as a poster at the International Society of Thrombosis and Haemostasis (ISTH) meeting 2009, Boston, USA.

PII: S0049-3848(09)00535-0

doi: 10.1016/j.thromres.2009.11.022

Thrombosis Research
Volume 125, Issue 3 , Pages 253-256 , March 2010

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