Thrombosis Research
Volume 126, Issue 3 , Pages e175-e179 , September 2010

The effect of aspirin on endothelial progenitor cell biology: Preliminary investigation of novel properties

  • Junyang Lou

      Affiliations

    • Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, USA
    • Contributed equally to the study and manuscript.
    • ,
  • Thomas J. Povsic

      Affiliations

    • Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, USA
    • Contributed equally to the study and manuscript.
    • ,
  • Jason D. Allen

      Affiliations

    • Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, USA
    • ,
  • Stacie D. Adams

      Affiliations

    • Duke University School of Medicine, USA
    • Duke University Medical Center, USA
    • ,
  • Shelley Myles

      Affiliations

    • Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, USA
    • ,
  • Aijing Z Starr

      Affiliations

    • Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, USA
    • ,
  • Thomas L. Ortel

      Affiliations

    • Department of Medicine, Division of Hematology, USA
    • ,
  • Richard C. Becker

      Affiliations

    • Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, USA
    • Department of Medicine, Division of Hematology, USA
    • Corresponding Author InformationCorresponding author. 2400 Pratt Street, Durham, NC 27705.

Received 30 September 2009 ,Revised 5 November 2009 ,Accepted 18 November 2009.

References 

  1. Campbell CL, Smyth S, Montalescot G, Steinhubl SR. Aspirin dose for the prevention of cardiovascular disease: A systematic review. JAMA. 2007;297:2018–2024
  2. Povsic T, Zavodni K, Kelly F, Zhu S, Goldschmidt-Clermont P, Dong C, et al. Circulating endogenous progenitor cells can be reliably identified on the basis of aldehyde dehydrogenase activity. J Am Coll Cardiol. 2007;53:2243–2248
  3. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the international brachial artery reactivity task force. J Am Coll Cardiol. 2002;39:257–265
  4. Welsch M, Allen J, Geaghan J. Stability and reproducibility of brachial artery flow-mediated dilatation. Med Sci Sports Exerc. 2002;34:960–965
  5. Conover W. Biometics. 1982;28:715–724
  6. Hill JM, Zalos G, Halcox JPJ, Schenke WH, Waclawiw MA, Quyyumi AA, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Eng J Med. 2003;348:593–600
  7. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 2001;89:e1–e7
  8. Santilli F, Romano M, Recchiuti A, Dragani A, Falco A, Lessiani G, et al. Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients. Blood. 2008;112:1085–1090
  9. Hu Z, Zhang F, Yang Z, Zhang J, Zhang D, Yang N, et al. Low-dose aspirin promotes endothelial progenitor cell migration and adhesion and prevents senescence. Cell Biol Int. 2008;32:761–768
  10. Mahdi JG, Mahdi AJ, Bowen ID. The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential. Cell Prolif. 2006;39:147–155
  11. Cai J, Cheng A, Luo Y, Lu C, Mattson MP, Rao MS, et al. Membrane properties of rat embryonic multipotent neural stem cells. J Neurochem. 2004;88:212–226
  12. Corti S, Locatelli F, Papadimitriou D, Donadoni C, Salani S, Del Bo R, et al. Identification of a primitive brain-derived neural stem cell population based on aldehyde dehydrogenase activity. Stem Cells. 2006;24:975–985
  13. Gentry T, Foster S, Winstead L, Deibert E, Fiordalisi M, Balber A. Simultaneous isolation of human bm hematopoietic, endothelial and mesenchymal progenitor cells by flow sorting based on aldehyde dehydrogenase activity: Implications for cell therapy. Cytotherapy. 2007;9:259–274
  14. Laird DJ, De Tomaso AW, Weissman IL. Stem cells are units of natural selection in a colonial ascidian. Cell. 2005;123:1351–1360
  15. Fallon P, Gentry T, Balber AE, Boulware D, Janssen WE, Smilee R, et al. Mobilized peripheral blood ssclo aldhbr cells have the phenotypic and functional properties of primitive haematopoietic cells and their number correlates with engraftment following autologous transplantation. Br J Haematol. 2003;122:99–108
  16. Povsic T, Adams SD, Zavodni KL, Kelly F, Melton L, Rao S, et al. Aldehyde dehydrogenase activity allows reliable epc enumeration in stored peripheral blood samples. J Thromb Thrombolysis. 2009;29:259–265
  17. Ajjan RA, Standeven KF, Khanbhai M, Phoenix F, Gersh KC, Weisel JW, et al. Effects of aspirin on clot structure and fibrinolysis using a novel in vitro cellular system. Arterioscler Thromb Vasc Biol. 2009;29:712–717
  18. He T, Lu T. d'Uscio LV, Lam CF, Lee HC, Katusic ZS: Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells. Circ Res. 2008;103:80–88
  19. Herrler T, Leicht S, Huber S, Hermann P, Schwarz T, Kopp T, et al. Prostaglandin e positively modulates endothelial progenitor cell homeostasis: An advanced treatment modality for autologous cell therapy. J Vasc Res. 2009;46:333–346
  20. Colleselli D, Bijuklic K, Mosheimer B, Kahler C. Inhibition of cyclooxygenase (cox)-2 affects endothelial progenitor cell proliferation. Exp Cell Res. 2006;312:2933–2941
  21. Chen T, Chen J, Xie X. Effect of apsirin on number, activity, and inducible nitric oxide synthase of endothelial progenitor cells from peripheral blood. Acta Phamacol Sin. 2006;27:430–436
  22. Deschaseaux F, Selmani Z, Falcoz P-E, Mersin N, Meneveau N, Penfornis A, et al. Two types of circulating endothelial progenitor cells in patients receiving long term therapy by HMG-CoA reductase inhibitors. Eur J Pharmacol. 2007;562:111–118
  23. Hristov M, Fach C, Becker C, Heussen N, Liehn EA, Blindt R, et al. Reduced numbers of circulating endothelial progenitor cells in patients with coronary artery disease associated with long-term statin treatment. Atherosclerosis. 2007;192:413–420
  24. Spyridopoulos I, Haendeler J, Urbich C, Brummendorf TH, Oh H, Schneider MD, et al. Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor trf2 in endothelial progenitor cells. Circulation. 2004;110:3136–3142
  25. Peters RJG, Mehta SR, Fox KAA, Zhao F, Lewis BS, Kopecky SL, et al. Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: Observations from the clopidogrel in unstable angina to prevent recurrent events (cure) study. Circulation. 2003;108:1682–1687
  26. So D, Cook EF, Le May M, Glover C, Williams W, Ha A, et al. Association of aspirin dosage to clinical outcomes after percutaneous coronary intervention: Observations from the Ottawa Heart Institute PCI registry. J Inv Cardiol. 2009;21:121–127

☆ This study was sponsored in part by Bayer Healthcare LLC.

PII: S0049-3848(09)00524-6

doi: 10.1016/j.thromres.2009.11.017

Thrombosis Research
Volume 126, Issue 3 , Pages e175-e179 , September 2010

Article Tools

* Image Usage & Resolution