Thrombosis Research
Volume 124, Issue 6 , Pages 653-655, December 2009

Heparin and maternal fetal interface: Why should it work to prevent pregnancy complications?

  • Nazli Hossain

      Affiliations

    • Department of Obstetrics & Gynecology Unit 3, Civil Hospital & Dow University of Health Sciences, Karachi, Pakistan
    • Corresponding Author InformationCorresponding author.
    • ,
  • Frederick Schatz

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB 339B, New Haven, CT 06520-8063, United States
    • ,
  • Michael J. Paidas

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB 339B, New Haven, CT 06520-8063, United States
    • Yale Women and Children's Center for Blood Disorders, United States
    • National Hemophilia Foundation- Baxter Clinical Fellowship Program at Yale, United States
    • Division of Maternal Fetal Medicine, Yale University School of Medicine, 333 Cedar Street, FMB 339B, New Haven, CT 06520-8063, United States
    • Tel.: +1 203 737 1982; fax: +1 203 737 2327.

Received 28 July 2009; received in revised form 28 July 2009; accepted 1 August 2009.

Abstract 

Anticoagulant therapy has been used extensively for the prevention of recurrent pregnancy losses, and other placenta mediated complications, including prevention of preeclampsia and fetal growth restriction. While heparin anticoagulation is a standard treatment for antiphospholipid antibody syndrome, it is increasingly being used in the prevention of placenta mediated complications. In this article, we explore the role of heparin at maternal-fetal interface, the molecular mechanism of action for heparin, and ongoing basic and translational work being done to elucidate heparin's principal mechanisms of action.

Keywords: anticoagulant therapy, maternal-fetal interface, adverse pregnancy outcome

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PII: S0049-3848(09)00338-7

doi:10.1016/j.thromres.2009.08.001

Thrombosis Research
Volume 124, Issue 6 , Pages 653-655, December 2009

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