Thrombosis Research
Volume 125, Issue 3 , Pages 224-229 , March 2010

Decreasing warfarin sensitivity during the first three months after heart valve surgery: Implications for dosing

  • K. Meijer

      Affiliations

    • Thrombosis Service, McMaster Clinic, HHS-General Hospital, Hamilton, Ontario, Canada
    • Division of Haemostasis, Thrombosis and Rheology, Department of Haematology, University Medical Centre Groningen, Groningen, The Netherlands
    • Corresponding Author InformationCorresponding author. Thrombosis Service, HHS-General Hospital, 237 Barton St E, Hamilton, Canada ON L8L 2X2. Tel.: +1 905 527 0271x44479; fax: +1 905 521 1551.
    • ,
  • Y.-K. Kim

      Affiliations

    • Thrombosis Service, McMaster Clinic, HHS-General Hospital, Hamilton, Ontario, Canada
    • Department of Medicine, Soonchunhyang University, Seoul, Korea
    • ,
  • S. Schulman

      Affiliations

    • Thrombosis Service, McMaster Clinic, HHS-General Hospital, Hamilton, Ontario, Canada

Received 27 January 2009 ,Revised 23 February 2009 ,Accepted 26 February 2009.

References 

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  2. Kulik A, Rubens FD, Wells PS, Kearon C, Mesana TG, van Berkom J, et al. Early postoperative anticoagulation after mechanical valve replacement: a systematic review. Ann Thorac Surg. 2006;81:770–781
  3. Ageno W, Turpie AG. Exaggerated initial response to warfarin following heart valve replacement. Am J Cardiol. 1999;84:905–908
  4. Rose JP, Rihn TL, Long SF. Warfarin sensitivity after mechanical heart valve replacement. Pharmacotherapy. 1998;18:856–859
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  6. Cade JF, Hirsh J, Clarebrough JK. Anticoagulants after open-heart surgery. Med J Aust. 1970;2:5–6
  7. Rosendaal FR, Cannegieter SC, Van der Meer FJ, Briët E. A method to determine the optimal intensity of oral anticoagulant therapy. Thromb Haemost. 1993;69:236–239
  8. Ionescu MI, Smith DR, Hasan SS, Chidambaram M, Tandon AP. Clinical durability of the pericardial xenograft valve: ten years experience with mitral replacement. Ann Thorac Surg. 1982;34:265–277
  9. Orszulak TA, Schaff HV, Pluth JR, Danielson GK, Puga FJ, Ilstrup DM, et al. The risk of stroke in the early postoperative period following mitral valve replacement. Eur J Cardiothorac Surg. 1995;9:615–619
  10. Schulman S, El Bouazzaoui B, Eikelboom JW, Zondag M. Clinical factors influencing the sensitivity to warfarin when restarted after surgery. J Intern Med. 2008;263:412–419
  11. Franco V, Polanczyk CA, Clausell N, Rohde LE. Role of dietary vitamin K intake in chronic oral anticoagulation: prospective evidence from observational and randomized protocols. Am J Med. 2004;116:651–656
  12. Parker CS, Chen Z, Price M, Gross R, Metlay JP, Christie JD, et al. Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study. Gen Intern Med. 2007;22:1254–1259
  13. Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G. American College of Chest Physicians. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:160S–198S
  14. Fitzmaurice DA, Kesteven P, Gee KM, Murray ET, McManus R. A systematic review of outcome measures reported for the therapeutic effectiveness of oral anticoagulation. J Clin Pathol. 2003;56:48–51

PII: S0049-3848(09)00122-4

doi: 10.1016/j.thromres.2009.02.012

Thrombosis Research
Volume 125, Issue 3 , Pages 224-229 , March 2010

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