« Previous
Next »
Thrombosis Research
Volume 124, Issue 4
, Pages 427-432
, September 2009
Procarboxypeptidase U (TAFI) contributes to the risk of thrombosis in patients with hereditary thrombophilia
References
- Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369:64–67
- . Activated protein C resistance and factor V Leiden: a review. Arch Pathol Lab Med. 2007;131:866–871
- . A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88:3698–3703
- . Venous thrombotic risk in family members of unselected individuals with factor V Leiden. Thromb Haemost. 2000;83:817–821
- . Elevated levels of prothrombin activation fragment 1 + 2 in plasma from patients with heterozygous Arg506 to Gln mutation in the factor V gene (APC-resistance) and/or inherited protein s deficiency. Thromb Haemost. 1996;75:270–274
- . Heightened thrombin generation in individuals with resistance to activated protein C. Thromb Haemost. 1996;75:703–705
- Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations. J Thromb Haemost. 2007;5:1444–1448
- Markers of activated coagulation in patients with factor V Leiden and/or G20210A prothrombin gene mutation. Thromb Res. 2002;107:7–11
- . Characterisation of a carboxypeptidase in human serum distinct from carboxypeptidase N. J Clin Chem Clin Biochem. 1989;27:277–285
- . Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. J Biol Chem. 1995;270:14477–14484
- . Discovery of thrombin activatable fibrinolysis inhibitor (TAFI). J Thromb Haemost. 2006;4:261–262
- . A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor. J Biol Chem. 1998;273:27176–27181
- . Regulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase B that unites the pathways of coagulation and fibrinolysis. Arterioscler Thromb Vasc Biol. 2006;26:2445–2453
- . TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J Biol Chem. 1996;271:16603–16608
- . A role for procarboxypeptidase U (TAFI) in thrombosis. Front Biosci. 2007;12:1973–1987
- . An antifibrinolytic mechanism describint the prothrombotic effect associated woth factor V Leiden. J Biol Chem. 1996;271:22949–22952
- . Factor V Leiden inhibitis fibrinolysis in vivo. Circulation. 2004;110:3594–3598
- . Two naturally occuring variants of TAFI (Thr-325 and Ile-325) differ substantially with respect to thermal stability and antifibrinolytic activity of the enzyme. J Biol Chem. 2002;277:1021–1030
- Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demostrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis. FEBS J. 2006;273:778–792
- Absolute risk of venous and arterial thromboembolism in thrombophilic families is not increased by high thrombin-activable fibrinolysis inhibitor (TAFI) levels. Thromb Haemost. 2008;100:38–44
- Co-segregation of thrombophilic disorders in factor V Leiden carriers; the contributions of factor VIII, factor XI, thrombin activatable fibrinolysis inhibitor and lipoprotein(a) to the absolute risk of venous thromboembolism. Haematologica. 2002;87:1068–1073
- . Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis. Blood. 2000;95:2855–2859
- . Fast kinetic assay for the determination of procarboxypeptidase U (TAFI) in human plasma. J Thromb Haemost. 2005;3:2353–2355
- . Influence of the Thr325Ile polymorphism on procarboxypeptidase U (TAFI) activity-based assays. J Thromb Haemost. 2007;5:872–875
- Correlates of thrombin markers in an elderly cohort free of clinical cardiovascular disease. Arterioscler Thromb Vasc Biol. 1996;16:1163–1169
- Thrombin-activatable fibrinolysis inhibitor in young patients with myocardial infarction and its relationship with the fibrinolytic function and the protein C system. Br J Haematol. 2003;122:958–965
- . On estimating the relation between blood group and disease. Am J Hum Genet. 1955;19:251–253
- A novel, possibly functional, single nucleotide polymorphism in the coding region of the thrombin-activatable fibrinolysis inhibitor (TAFI) gene is also associated with TAFI levels. Blood. 2001;98:1992–1993
- . Thrombin-activable fibrinolysis inhibitor antigen and TAFI activity in patients with APC resistance caused by factor V Leiden mutation. Thromb Res. 2002;106:59–62
- Reduced activity of TAFI (thrombin-activable fibrinolysis inhibitor) in acute promyelocytic leukaemia. Br J Haematol. 2000;108:518–523
- . Venous thromboembolism: disease burden, outcomes and risk factors. J Thromb Haemost. 2005;3:1611–1617
- . Factor V Leiden and risks of recurrent idiopathic venous thromboembolism. Circulation. 1995;92:2800–2802
- Risk of subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep vein thrombosis. Blood. 2000;96:3329–3333
- Thrombin-activatable fibrinolysis inhibitor and the risk for recurrent venous thromboembolism. Blood. 2004;103:3773–3776
- . Thr325Ile polymorphism in the TAFI gene does not influence the risk of myocardial infarction. Blood. 2002;99:1878–1879
PII: S0049-3848(09)00029-2
doi: 10.1016/j.thromres.2009.01.005
© 2009 Elsevier Ltd. All rights reserved.
« Previous
Next »
Thrombosis Research
Volume 124, Issue 4
, Pages 427-432
, September 2009
