Thrombosis Research
Volume 122 , Pages S9-S15 , 2008

Pre-clinical studies of plasmin: Superior benefit-to-risk ratio of plasmin compared to tissue plasminogen activator

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  6. Marder VJ, Sherry S. Thrombolytic therapy: current status (2). N Engl J Med. 1988;318:1585–1595
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  8. Marder VJ, Landskroner K, Novokhatny V, et al. Plasmin induces local thrombolysis without causing hemorrhage: a comparison with tissue plasminogen activator in the rabbit. Thromb Haemost. 2001;86:739–745
  9. Collen D. On the regulation and control of fibrinolysis. Thromb Haemost. 1980;43:77–89
  10. Stewart D, Kong M, Novokhatny V. Distinct dose-dependent effects of plasmin and TPA on coagulation and hemorrhage. Blood. 2003;101:3002–3007
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  12. Jahan R, Stewart D, Vinters HV, et al. Middle cerebral artery occlusion in the rabbit using selective angiography: application for assessment of thrombolysis. Stroke. 2008;39:1613–1615

☆ Supported by Grant RO1 HL 074051 from the National Heart Lung and Blood Institute, NIH, Bethesda, MD, and by a grant from Talecris BioTherapeutics, RTP, NC.

PII: S0049-3848(08)00239-9

doi: 10.1016/j.thromres.2008.06.019

Thrombosis Research
Volume 122 , Pages S9-S15 , 2008

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