Thrombosis Research
Volume 122, Issue 3 , Pages 328-335, 2008

The urokinase-type plasminogen activator/its soluble receptor system is independently related to carotid atherosclerosis and associated with CC-chemokines in uraemic patients

  • Krystyna Pawlak

      Affiliations

    • Department of Monitored Pharmacotherapy, Medical University of Bialystok, Mickiewicza 2C Street, 15-089 Bialystok, Poland
    • Corresponding Author InformationCorresponding author. Tel./fax: +48 85 7485601.
    • ,
  • Michal Mysliwiec

      Affiliations

    • Department of Nephrology and Clinical Transplantation, Medical University, Bialystok, Poland
    • ,
  • Dariusz Pawlak

      Affiliations

    • Department of Monitored Pharmacotherapy, Medical University of Bialystok, Mickiewicza 2C Street, 15-089 Bialystok, Poland

Received 4 June 2007; received in revised form 14 September 2007; accepted 23 October 2007.

Abstract 

Introduction

The urokinase-type plasminogen activator (uPA)/its soluble receptor (suPAR) and CC-chemokines are two systems contributing in the atherosclerosis. We try to establish whether these two systems were associated among themselves, and the significance of this potential association in relation to carotid atherosclerosis in uraemic patients.

Materials and methods

We determined uPA, suPAR, CC-chemokines: monocyte chemoattractant protein-1 (CCL2), macrophage inflammatory proteins (CCL3, CCL4), regulated upon activation, normal T cell expressed and secreted (CCL5) and the intima-media thickness (IMT) values in uraemic patients on peritoneal dialysis (CAPD), haemodialysis (HD) and healthy controls.

Results

The values of the uPA/suPAR system, CCL2, CCL4 and IMT in the patients significantly exceeded those in controls, whereas CCL5 were lower in the patients than in the controls. CCL3 concentrations were similar in all investigated groups. CCL2, CCL4 and CCL5 were positively associated with uPA/suPAR system. CCL2 and CCL4 were associated with IMT. Multivariate analysis showed that uPA, suPAR and age were the strong independent variables linked to IMT values.

Conclusions

The carotid atherosclerosis is independently related to uPA/its soluble receptor system in dialysis patients. In addition, the strong positive associations existed between uPA/suPAR system and CC-chemokines suggesting that these two systems could cooperate and influence of atherosclerosis in these patients.

Keywords: Atherosclerosis, CC-chemokines, Haemodialysis, Peritoneal dialysis, uPA/suPAR system

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PII: S0049-3848(07)00404-5

doi:10.1016/j.thromres.2007.10.017

Thrombosis Research
Volume 122, Issue 3 , Pages 328-335, 2008

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