Thrombosis Research
Volume 121, Issue 3 , Pages 361-367 , 2007

Detection of shortened activated partial thromboplastin times: An evaluation of different commercial reagents

Received 14 February 2007 ,Revised 2 May 2007 ,Accepted 5 May 2007.

References 

  1. Lane DA, Grant PJ. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood. 2000;95:1517–1532
  2. Koster T, Blann AD, Briet E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet. 1995;345:152–155
  3. Kraaijenhagen RA, in 't Anker PS, Koopman MM, Reitsma PH, Prins MH, van den Ende A, et al. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism. Thromb Haemost. 2000;83:5–9
  4. Meijers JC, Tekelenburg WL, Bouma BN, Bertina RM, Rosendaal FR. High levels of coagulation factor XI as a risk factor for venous thrombosis. N Engl J Med. 2000;342:696–701
  5. O'Donnell J, Tuddenham EG, Manning R, Kemball-Cook G, Johnson D, Laffan M. High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction. Thromb Haemost. 1997;77:825–828
  6. van Hylckama Vlieg A, van der Linden I, Bertina RM, Rosendaal FR. High levels of factor IX increase the risk of venous thrombosis. Blood. 2000;95:3678–3682
  7. Korte W, Clarke S, Lefkowitz JB. Short activated partial thromboplastin times are related to increased thrombin generation and an increased risk for thromboembolism. Am J Clin Pathol. 2000;113:123–127
  8. Landi G, D'Angelo A, Boccardi E, Candelise L, Mannucci PM, Morabito A, et al. Venous thromboembolism in acute stroke. Prognostic importance of hypercoagulability. Arch Neurol. 1992;49:279–283
  9. Reddy NM, Hall SW, MacKintosh FR. Partial thromboplastin time: prediction of adverse events and poor prognosis by low abnormal values. Arch Intern Med. 1999;159:2706–2710
  10. ten Boekel E, de Kieviet W, Bartels PC. Subjects with a shortened activated partial thromboplastin time show increased in-hospital mortality associated with elevated D-dimer, C-reactive protein and glucose levels. Scand J Clin Lab Invest. 2003;63:441–448
  11. Hron G, Eichinger S, Weltermann A, Quehenberger P, Halbmayer WM, Kyrle PA. Prediction of recurrent venous thromboembolism by the activated partial thromboplastin time. J Thromb Haemost. 2006;4:752–756
  12. Legnani C, Mattarozzi S, Cini M, Cosmi B, Favaretto E, Palareti G. Abnormally short activated partial thromboplastin time values are associated with increased risk of recurrence of venous thromboembolism after oral anticoagulation withdrawal. Br J Haematol. 2006;134:227–232
  13. Tripodi A, Chantarangkul V, Martinelli I, Bucciarelli P, Mannucci PM. A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. Blood. 2004;104:3631–3634
  14. ten Boekel E, Bartels P. Abnormally short activated partial thromboplastin times are related to elevated plasma levels of TAT, F1+2, D-dimer and FVIII:C. Pathophysiol Haemost Thromb. 2002;32:137–142
  15. Tripodi A, Chantarangkul V, Asti D, Martinelli I, Mannucci PM. Activated partial thromboplastin time: results of a case–control study evaluating six commercial reagents in assessing the risk of venous thromboembolism. J Thromb Haemost. 2006;4:1407–1409
  16. Bick RL. Disseminated intravascular coagulation: pathophysiological mechanisms and manifestations. Semin Thromb Hemost. 1998;24:3–18
  17. Brotman DJ, Girod JP, Posch A, Jani JT, Patel JV, Gupta M, et al. Effects of short-term glucocorticoids on hemostatic factors in healthy volunteers. Thromb Res. 2006;118:247–252
  18. Ibbotson SH, Rayner H, Stickland MH, Davies JA, Grant PJ. Thrombin generation and factor VIII:C levels in patients with type 1 diabetes complicated by nephropathy. Diabet Med. 1993;10:336–340
  19. Jern C, Eriksson E, Tengborn L, Risberg B, Wadenvik H, Jern S. Changes of plasma coagulation and fibrinolysis in response to mental stress. Thromb Haemost. 1989;62:767–771
  20. Lombardi R, Mannucci PM, Seghatchian MJ, Garcia VV, Coppola R. Alterations of factor VIII von Willebrand factor in clinical conditions associated with an increase in its plasma concentration. Br J Haematol. 1981;49:61–68
  21. O'Donnell J, Mumford AD, Manning RA, Laffan MA. Marked elevation of thrombin generation in patients with elevated FVIII:C and venous thromboembolism. Br J Haematol. 2001;115:687–691

PII: S0049-3848(07)00211-3

doi: 10.1016/j.thromres.2007.05.006

Thrombosis Research
Volume 121, Issue 3 , Pages 361-367 , 2007

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