Platelet aggregation abnormalities in patients with recurrent fetal losses

Abstract 

Introduction

There are some studies reporting that platelets might have a role in cases with recurrent fetal losses. The aim of this study is to evaluate the importance of platelet aggregation abnormalities in this patient group.

Materials and methods

In this study, platelet aggregation abnormalities were compared in 56 cases with recurrent fetal losses (29 of these 56 patients have ≥3 losses) and in 33 healthy female controls with no previous history of fetal loss. Platelet aggregation studies were performed with optical turbidometric method by using ADP (5 μM), collagen (0.2 mg/ml) and epinephrine (10 μM).

Results

We did not find any statistically significant difference between patient (56 cases with ≥2 fetal losses and 29 of them with ≥3 fetal losses) and control groups for platelet aggregation abnormalities.

Conclusions

The data we have obtained suggest that severe platelet aggregation abnormalities are not the rule in patients with recurrent fetal losses.

Keywords: Abortion habitual, Platelet aggregation, Platelet function, Thrombosis