Thrombosis Research
Volume 121, Issue 3 , Pages 333-338 , 2007

Fibrinogen Aα-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolism

  • Grégoire Le Gal

      Affiliations

    • EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    • Corresponding Author InformationCorresponding author. EA 3878 (GETBO), Department of Internal Medicine and Chest Diseases, Hôpital de la Cavale Blanche F-29609 Brest Cedex, France. Tel.: +33 2 98 34 73 36; fax: +33 2 98 34 79 44.
    • ,
  • Bénédicte Delahousse

      Affiliations

    • Department of Haematology-Haemostasis, Trousseau Hospital, Tours, France
    • ,
  • Karine Lacut

      Affiliations

    • EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    • ,
  • Vincent Malaviolle

      Affiliations

    • EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    • ,
  • Sandra Regina

      Affiliations

    • Department of Haematology-Haemostasis, Trousseau Hospital, Tours, France
    • INSERM U618 “Protéases et Vectorisation pulmonaires”, University Francois Rabelais, Tours, France
    • ,
  • Marie-Thérèse Blouch

      Affiliations

    • Laboratory of Haemostasis, Brest University Hospital, Brest, France
    • ,
  • Francis Couturaud

      Affiliations

    • EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    • ,
  • Dominique Mottier

      Affiliations

    • EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    • ,
  • Emmanuel Oger

      Affiliations

    • Centre of Clinical Investigations INSERM CIC-0502, Brest University Hospital, Brest, France
    • ,
  • Yves Gruel

      Affiliations

    • Department of Haematology-Haemostasis, Trousseau Hospital, Tours, France
    • INSERM U618 “Protéases et Vectorisation pulmonaires”, University Francois Rabelais, Tours, France
    • ,
  • on behalf of the “Groupe d'Etudes sur la Thrombose des Hôpitaux Universitaires du Grand Ouest” (GET-HUGO)

Received 23 December 2006 ,Revised 6 April 2007 ,Accepted 1 May 2007.

References 

  1. Wolberg AS, Monroe DM, Roberts HR, Hoffman M. Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk. Blood. 2003;101:3008–3013
  2. Ariens RA, Philippou H, Nagaswami C, Weisel JW, Lane DA, Grant PJ. The factor XIII V34L polymorphism accelerates thrombin activation of factor XIII and affects cross-linked fibrin structure. Blood. 2000;96:988–995
  3. Wartiovaara U, Mikkola H, Szoke G, Haramura G, Karpati L, Balogh I, et al. Effect of Val34Leu polymorphism on the activation of the coagulation factor XIII-A. Thromb Haemost. 2000;84:595–600
  4. Ariens RA, Lai TS, Weisel JW, Greenberg CS, Grant PJ. Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms. Blood. 2002;100:743–754
  5. Alhenc-Gelas M, Reny JL, Aubry ML, Aiach M, Emmerich J. The FXIII Val 34 Leu mutation and the risk of venous thrombosis. Thromb Haemost. 2000;84:1117–1118
  6. Corral J, Gonzalez-Conejero R, Iniesta JA, Rivera J, Martinez C, Vicente V. The FXIII Val34Leu polymorphism in venous and arterial thromboembolism. Haematologica. 2000;85:293–297
  7. Scott EM, Ariens RA, Grant PJ. Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease. Arterioscler Thromb Vasc Biol. 2004;24:1558–1566
  8. Standeven KF, Grant PJ, Carter AM, Scheiner T, Weisel JW, Ariens RA. Functional analysis of the fibrinogen Aalpha Thr312Ala polymorphism: effects on fibrin structure and function. Circulation. 2003;107:2326–2330
  9. Carter AM, Catto AJ, Kohler HP, Ariens RA, Stickland MH, Grant PJ. alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism. Blood. 2000;96:1177–1179
  10. Oger E, Lacut K, Le Gal G, Couturaud F, Guenet D, Abalain JH, et al. Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study. J Thromb Haemost. 2006;4:793–799
  11. The PIOPED investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA. 1990;263:2753–2759
  12. Balogh I, Szoke G, Karpati L, Wartiovaara U, Katona E, Komaromi I, et al. Val34Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia. Blood. 2000;96:2479–2486
  13. Oger E, Lacut K, Le Gal G, Van Dreden P, Bressollette L, Scarabin PY, et al. Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?. Thromb Haemost. 2002;88:587–591
  14. Catto AJ, Kohler HP, Coore J, Mansfield MW, Stickland MH, Grant PJ. Association of a common polymorphism in the factor XIII gene with venous thrombosis. Blood. 1999;93:906–908
  15. Wells PS, Anderson JL, Rodger MA, Carson N, Grimwood RL, Doucette SP. The factor XIII Val34Leu polymorphism: is it protective against idiopathic venous thromboembolism?. Blood Coagul Fibrinolysis. 2006;17:533–538
  16. Wells PS, Anderson JL, Scarvelis DK, Doucette SP, Gagnon F. Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and meta-analysis. Am J Epidemiol. 2006;164:101–109
  17. Carter AM, Catto AJ, Grant PJ. Association of the alpha-fibrinogen Thr312Ala polymorphism with poststroke mortality in subjects with atrial fibrillation. Circulation. 1999;99:2423–2426
  18. Baumann RE, Henschen AH. Human fibrinogen polymorphic site analysis by restriction endonuclease digestion and allele-specific polymerase chain reaction amplification: identification of polymorphisms at positions A alpha 312 and B beta 448. Blood. 1993;82:2117–2124
  19. Curran JM, Evans A, Arveiler D, Luc G, Ruidavets JB, Humphries SE, et al. The alpha fibrinogen T/A312 polymorphism in the ECTIM study. Thromb Haemost. 1998;79:1057–1058
  20. Van Hylckama Vlieg A, Komanasin N, Ariens RA, Poort SR, Grant PJ, Bertina RM, et al. Factor XIII Val34Leu polymorphism, factor XIII antigen levels and activity and the risk of deep venous thrombosis. Brit J Haematol. 2002;119:169–175

☆ GLG collected data, analyzed data and wrote the paper; BD performed research and wrote the paper; KL collected data; VM performed research; SR performed research; MTB collected data; FC collected data; DM designed research; EO designed research and collected data; YG designed research and wrote the paper.

PII: S0049-3848(07)00208-3

doi: 10.1016/j.thromres.2007.05.003

Thrombosis Research
Volume 121, Issue 3 , Pages 333-338 , 2007

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