Thrombosis Research
Volume 121, Issue 2 , Pages 225-234 , 2007

In vivo response to vascular injury in the absence of factor IX: Examination in factor IX knockout mice

  • Tong Gui

      Affiliations

    • Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
    • Gene Therapy Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
    • These authors contributed equally.
    • ,
  • Adili Reheman

      Affiliations

    • Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada M5B1W8
    • These authors contributed equally.
    • ,
  • William K. Funkhouser

      Affiliations

    • Department of Pathology and Laboratory of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
    • ,
  • Dwight A. Bellinger

      Affiliations

    • Department of Pathology and Laboratory of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
    • ,
  • John R. Hagaman

      Affiliations

    • Department of Pathology and Laboratory of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
    • ,
  • Darrel W. Stafford

      Affiliations

    • Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
    • ,
  • Paul E. Monahan

      Affiliations

    • Gene Therapy Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
    • Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
    • Corresponding Author InformationCorresponding author. Department of Pediatrics, Division of Hematology/Oncology, CB #7220, GR 3315 Gravely Building, Chapel Hill, NC 27599-7220, United States. Tel.: +1 919 843 4985; fax: +1 919 966 0907.
    • ,
  • Heyu Ni

      Affiliations

    • Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada M5B1W8
    • Canadian Blood Services, Toronto, Ontario, Canada M5B1W8

Received 26 November 2006 ,Revised 22 March 2007 ,Accepted 30 March 2007.

References 

  1. Lawson JH, Mann KG. Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation. J Biol Chem. 1991;266:11317–11327
  2. Hoffman M, Monroe DM, Oliver JA, Roberts HR. Factors IXa and Xa play distinct roles in tissue factor-dependent initiation of coagulation. Blood. 1995;86:1794–1801
  3. Heemskerk JW, Kuijpers MJ, Munnix IC, Siljander PR. Platelet collagen receptors and coagulation. A characteristic platelet response as possible target for antithrombotic treatment. Trends Cardiovasc Med. 2005;15:86–92
  4. Lu G, Broze GJ, Krishnaswamy S. Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III. J Biol Chem. 2004;279:17241–17249
  5. Kempton CL, Hoffman M, Roberts HR, Monroe DM. Platelet heterogeneity: variation in coagulation complexes on platelet subpopulations. Arterioscler Thromb Vasc Biol. 2005;25:861–866
  6. Butenas S, Orfeo T, Gissel MT, Brummel KE, Mann KG. The significance of circulating factor IXa in blood. J Biol Chem. 2004;279:22875–22882
  7. Butenas S, Brummel KE, Branda RF, Paradis SG, Mann KG. Mechanism of factor VIIa-dependent coagulation in hemophilia blood. Blood. 2002;99:923–930
  8. Monroe DM, Hoffman M, Roberts HR. Platelets and thrombin generation. Arterioscler Thromb Vasc Biol. 2002;22:1381–1389
  9. Macfarlane RG. An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature. 1964;202:498–499
  10. Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science. 1964;145:1310–1312
  11. Wang X, Cheng Q, Xu L, Feuerstein GZ, Hsu MY, Smith PL, et al. Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice. J Thromb Haemost. 2005;3:695–702
  12. Renne T, Pozgajova M, Gruner S, Schuh K, Pauer HU, Burfeind P, et al. Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med. 2005;202:271–281
  13. Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer HU, Burfeind P, et al. Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med. 2006;203:513–518
  14. Pauer HU, Renne T, Hemmerlein B, Legler T, Fritzlar S, Adham I, et al. Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo. Thromb Haemost. 2004;92:503–508
  15. Lin HF, Maeda N, Smithies O, Straight DL, Stafford DW. A coagulation factor IX-knockout mouse model for human hemophilia B. Blood. 1997;90:3962–3966
  16. Chao H, Monahan PE, Liu Y, Samulski RJ, Walsh CE. Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors. Mol Ther. 2001;4:217–222
  17. Lindner V, Fingerle J, Reidy MA. Mouse model of arterial injury. Circ Res. 1993;73:792–796
  18. Schwartz RS, Holmes DR, Topol EJ. The restenosis paradigm revisited: an alternative proposal for cellular mechanisms. J Am Coll Cardiol. 1992;20:1284–1293
  19. Ni H, Denis CV, Subbarao S, Degen JL, Sato TN, Hynes RO, et al. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest. 2000;106:385–392
  20. Ni H, Papalia JM, Degen JL, Wagner DD. Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Blood. 2003;102:3609–3614
  21. Ni H, Ramakrishnan V, Ruggeri ZM, Papalia JM, Phillips DR, Wagner DD. Increased thrombogenesis and embolus formation in mice lacking glycoprotein V. Blood. 2001;98:368–373
  22. Ni H, Yuen PS, Papalia JM, Trevithick JE, Sakai T, Fassler R, et al. Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A. 2003;100:2415–2419
  23. Renne T, Nieswandt B, Gailani D. The intrinsic pathway of coagulation is essential for thrombus stability in mice. Blood Cells Mol Dis. 2006;36:148–151
  24. Yamashita A, Nishihira K, Kitazawa T, Yoshihashi K, Soeda T, Esaki K, et al. Factor XI contributes to thrombus propagation on injured neointima of the rabbit iliac artery. J Thromb Haemost. 2006;4:1496–1501
  25. Sudo T, Ito H, Kimura Y. Genetic strain differences in platelet aggregation of laboratory mice. Thromb Haemost. 2006;95:159–165
  26. Tschopp TB, Weiss HJ, Baumgartner HR. Decreased adhesion of platelets to subendothelium in von Willebrand's disease. J Lab Clin Med. 1974;83:296–300
  27. Weiss HJ, Tschopp TB, Baumgartner HR. Impaired interaction (adhesion–aggregation) of platelets with the subendothelium in storage-pool disease and after aspirin ingestion. A comparison with von Willebrand's disease. N Engl J Med. 1975;293:619–623
  28. Bennett JS, Vilaire G. Exposure of platelet fibrinogen receptors by ADP and epinephrine. J Clin Invest. 1979;64:1393–1401
  29. Shirasawa K, Barton BP, Chandler AB. Localization of ferritin-conjugated anti-fibrin-fibrinogen in platelet aggregates produced in vitro. Am J Pathol. 1972;66:379–406
  30. Weiss HJ, Rogers J. Fibrinogen and platelets in the primary arrest of bleeding. Studies in two patients with congenital afibrinogenemia. N Engl J Med. 1971;285:369–374
  31. Hansen MS, Clemmensen I. A fibronectin-binding glycoprotein from human platelet membranes. Biochem J. 1982;201:629–633
  32. Reheman A, Gross P, Yang H, Chen P, Allen D, Leytin V, et al. Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemost. 2005;3:875–883
  33. Sun WY, Witte DP, Degen JL, Colbert MC, Burkart MC, Holmback K, et al. Prothrombin deficiency results in embryonic and neonatal lethality in mice. Proc Natl Acad Sci U S A. 1998;95:7597–7602
  34. Xue J, Wu Q, Westfield LA, Tuley EA, Lu D, Zhang Q, et al. Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice. Proc Natl Acad Sci U S A. 1998;95:7603–7607
  35. Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, et al. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J Thromb Haemost. 2006;4:2230–2237
  36. Kung SH, Hagstrom JN, Cass D, Tai SJ, Lin HF, Stafford DW, et al. Human factor IX corrects the bleeding diathesis of mice with hemophilia B. Blood. 1998;91:784–790
  37. Toomey JR, Valocik RE, Koster PF, Gabriel MA, McVey M, Hart TK, et al. Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke. Stroke. 2002;33:578–585
  38. Choudhri TF, Hoh BL, Prestigiacomo CJ, Huang J, Kim LJ, Schmidt AM, et al. Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. J Exp Med. 1999;190:91–99
  39. Rusconi CP, Roberts JD, Pitoc GA, Nimjee SM, White RR, Quick G, et al. Antidote-mediated control of an anticoagulant aptamer in vivo. Nat Biotechnol. 2004;22:1423–1428
  40. Nimjee SM, Keys JR, Pitoc GA, Quick G, Rusconi CP, Sullenger BA. A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery. Mol Ther. 2006;14:408–415
  41. Yarovoi HV, Kufrin D, Eslin DE, Thornton MA, Haberichter SL, Shi Q, et al. Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood. 2003;102:4006–4013

PII: S0049-3848(07)00127-2

doi: 10.1016/j.thromres.2007.03.026

Thrombosis Research
Volume 121, Issue 2 , Pages 225-234 , 2007

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